evidence table

N-Acetylcysteine Oxidative Stress Meta-Analysis Evidence Table

Structured evidence table for N-Acetylcysteine Oxidative Stress Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
N-Acetylcysteine Oxidative Stress Meta-AnalysisConclusion Our meta-analysis indicates that N-acetylcysteine, when compared to placebo, does not demonstrate consistent efficacy in reducing the primary symptoms of AUD or PTSD in broad patient populations.1Ahmed MAE (2026)N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
N-Acetylcysteine Oxidative Stress Meta-AnalysisIntroduction Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are thought to be significant global contributors to the burden of mental illness.1Ahmed MAE (2026)N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
N-Acetylcysteine Oxidative Stress Meta-AnalysisAccording to recent WHO epidemiological estimates, 3.9% of people worldwide have experienced PTSD at some point in their lives; this number rises to roughly 5.6% among those who have experienced trauma.1Ahmed MAE (2026)N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
N-Acetylcysteine Oxidative Stress Meta-AnalysisThis document consolidates existing evidence to this effect, and adds insights from practicing clinicians to guide about use of NAC in clinical practice.2Barne M (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
N-Acetylcysteine Oxidative Stress Meta-AnalysisConclusion This consensus underscores the role of NAC in chronic respiratory diseases beyond its mucolytic properties and reiterates that NAC's antioxidant, anti-inflammatory, immunomodulatory and anti-biofilm properties provide significant clinical utility.2Barne M (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
N-Acetylcysteine Oxidative Stress Meta-AnalysisWhile promising for TB and respiratory infections, further evidence is required.2Barne M (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
N-Acetylcysteine Oxidative Stress Meta-AnalysisBackground N-acetylcysteine (NAC) is a key precursor of glutathione (GSH), the lung's principal antioxidant.2Barne M (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimConclusion Our meta-analysis indicates that N-acetylcysteine, when compared to placebo, does not demonstrate consistent efficacy in reducing the primary symptoms of AUD or PTSD in broad patient populations.
evidence level1
citationAhmed MAE (2026)
sourceN-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimIntroduction Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are thought to be significant global contributors to the burden of mental illness.
evidence level1
citationAhmed MAE (2026)
sourceN-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimAccording to recent WHO epidemiological estimates, 3.9% of people worldwide have experienced PTSD at some point in their lives; this number rises to roughly 5.6% among those who have experienced trauma.
evidence level1
citationAhmed MAE (2026)
sourceN-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimThis document consolidates existing evidence to this effect, and adds insights from practicing clinicians to guide about use of NAC in clinical practice.
evidence level2
citationBarne M (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimConclusion This consensus underscores the role of NAC in chronic respiratory diseases beyond its mucolytic properties and reiterates that NAC's antioxidant, anti-inflammatory, immunomodulatory and anti-biofilm properties provide significant clinical utility.
evidence level2
citationBarne M (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimWhile promising for TB and respiratory infections, further evidence is required.
evidence level2
citationBarne M (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).
topicN-Acetylcysteine Oxidative Stress Meta-Analysis
claimBackground N-acetylcysteine (NAC) is a key precursor of glutathione (GSH), the lung's principal antioxidant.
evidence level2
citationBarne M (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).

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Source documents

  1. N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
  2. N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).