topicMyo-Inositol Stress Meta-Analysis
claimCombination therapy significantly reduced TSH levels compared with Sel monotherapy (SMD -1.26; 95% CI -1.51 to -1.00; p 2 = 0%), and TSA suggested that this finding may be robust, although the evidence is limited by the small number of studies.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicMyo-Inositol Stress Meta-Analysis
claimTgAb levels were also significantly reduced (SMD -0.51; 95% CI -0.78 to -0.24; p 2 = 0%); however, TSA indicated a potential risk of type I error.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicMyo-Inositol Stress Meta-Analysis
claimConclusions : MI combined with Sel was associated with a significant reduction in TSH levels compared with Sel alone in patients with HT and subclinical hypothyroidism, suggesting a potential therapeutic benefit.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicMyo-Inositol Stress Meta-Analysis
claimIntroduction : Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism in iodine-sufficient regions and often presents with subclinical hypothyroidism.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicMyo-Inositol Stress Meta-Analysis
claimAnxiety and depressive disorders frequently co-occur, and converging evidence from symptom profiles, longitudinal course, shared neurobiological markers, familial aggregation, and treatment response supports a substantial overlap between these conditions [].
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review
topicMyo-Inositol Stress Meta-Analysis
claimImportantly, even agents considered comparatively “benign”, such as non-benzodiazepine anxiolytics, may rarely cause significant neurological adverse effects in vulnerable individuals, as illustrated by reports of buspirone-associated dyskinesia or dystonia, plausibly related to its interactions with dopaminergic signaling [].
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review
topicMyo-Inositol Stress Meta-Analysis
claimRecent reports have also raised the possibility that selected cyclitols may exert anxiolytic activity; however, robust clinical evidence remains scarce, and the available data are largely preliminary, often derived from indirect observations or preclinical research [].
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review
topicMyo-Inositol Stress Meta-Analysis
claim1 2 3 4 1 Anxiety plays a dual role, encompassing both adaptive and maladaptive dimensions.
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review