topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claimThe global prevalence of PCOS increased from 36.7 to 69.5 million between 1990 and 2021.
evidence level3
citationSubakathulla Sumayyah (2026)
sourceRedox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails?
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claimEmerging evidence underscores that OS is not a mere byproduct of metabolic imbalance but a central driver that disrupts insulin signaling, amplifies androgen biosynthesis, and impairs folliculogenesis (,).
evidence level3
citationSubakathulla Sumayyah (2026)
sourceRedox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails?
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claimLow-dose variants of OCPs have been observed with an increased risk of myocardial infarction and cardiovascular arterial disease ().
evidence level3
citationSubakathulla Sumayyah (2026)
sourceRedox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails?
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claim1 2 3 4 5 Polycystic ovary syndrome (PCOS) represents one of the most complex endocrine-metabolic disorders affecting women of reproductive age, characterized by a collection of reproductive, metabolic, and psychological manifestations (,).
evidence level3
citationSubakathulla Sumayyah (2026)
sourceRedox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails?
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claim1 2 3 4 Polycystic ovary syndrome (PCOS) is among the most frequent endocrine disorders in women of reproductive age and is strongly associated with multiple cardiometabolic disturbances.
evidence level4
citationMuacevic Alexander (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claimWhile these approaches can reduce symptoms, they mostly do not address the underlying endocrine or metabolic disturbances and may be associated with adverse effects, including gastrointestinal discomfort, weight gain, and fatigue [,].
evidence level4
citationMuacevic Alexander (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claimIncreasing evidence also points to the benefits of curcumin, a polyphenolic compound from turmeric, which down-regulates inflammatory mediators and oxidative stress, thereby improving insulin action [].
evidence level4
citationMuacevic Alexander (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review
topicMyo-Inositol Insulin Sensitivity Meta-Analysis
claimGlobally, the condition affects roughly 4-20% of women, underscoring its significance as a public-health concern [,].
evidence level4
citationMuacevic Alexander (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review