evidence table

Myo-Inositol Insulin Resistance Meta-Analysis Evidence Table

Structured evidence table for Myo-Inositol Insulin Resistance Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Myo-Inositol Insulin Resistance Meta-AnalysisObjectives This umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of the existing body of evidence.2Duan M (2026)Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
Myo-Inositol Insulin Resistance Meta-AnalysisGRADE assessment of 85 evidence items revealed no high-quality evidence; 18.9% were moderate, 40% low, and 41.1% very low quality.2Duan M (2026)Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
Myo-Inositol Insulin Resistance Meta-AnalysisPooled analyses demonstrated that inositol significantly improved multiple outcomes compared to placebo/FA: it reduced serum luteinizing hormone (LH: MD -3.43 IU/L, 95% CI [-4.29, -2.56], P P P P P P = 0.03; ovulation rate: RR 2.75, 95% CI [1.71, 4.41], P Conclusion Inositol improves core PCOS manifestations.2Duan M (2026)Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
Myo-Inositol Insulin Resistance Meta-AnalysisMethods We searched four databases from inception to August 2025 for relevant RCT meta-analyses.2Duan M (2026)Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
Myo-Inositol Insulin Resistance Meta-AnalysisConclusions and outlook Myo-inositol has a more acceptable safety profile than metformin, which is known to be associated with gastrointestinal adverse effects and, in rare cases, lactic acidosis.4Russo M (2025)Metformin and Myo-Inositol: A Comparative Analysis.
Myo-Inositol Insulin Resistance Meta-AnalysisBackground In the field of polycystic ovary syndrome (PCOS), metformin and myo-inositol are frequently employed to treat the endocrine-metabolic aspects of the condition.4Russo M (2025)Metformin and Myo-Inositol: A Comparative Analysis.
Myo-Inositol Insulin Resistance Meta-AnalysisAccordingly, myo-inositol is sometimes considered as a nutraceutical alternative for metformin.4Russo M (2025)Metformin and Myo-Inositol: A Comparative Analysis.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimObjectives This umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of the existing body of evidence.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimGRADE assessment of 85 evidence items revealed no high-quality evidence; 18.9% were moderate, 40% low, and 41.1% very low quality.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimPooled analyses demonstrated that inositol significantly improved multiple outcomes compared to placebo/FA: it reduced serum luteinizing hormone (LH: MD -3.43 IU/L, 95% CI [-4.29, -2.56], P P P P P P = 0.03; ovulation rate: RR 2.75, 95% CI [1.71, 4.41], P Conclusion Inositol improves core PCOS manifestations.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimMethods We searched four databases from inception to August 2025 for relevant RCT meta-analyses.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimConclusions and outlook Myo-inositol has a more acceptable safety profile than metformin, which is known to be associated with gastrointestinal adverse effects and, in rare cases, lactic acidosis.
evidence level4
citationRusso M (2025)
sourceMetformin and Myo-Inositol: A Comparative Analysis.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimBackground In the field of polycystic ovary syndrome (PCOS), metformin and myo-inositol are frequently employed to treat the endocrine-metabolic aspects of the condition.
evidence level4
citationRusso M (2025)
sourceMetformin and Myo-Inositol: A Comparative Analysis.
topicMyo-Inositol Insulin Resistance Meta-Analysis
claimAccordingly, myo-inositol is sometimes considered as a nutraceutical alternative for metformin.
evidence level4
citationRusso M (2025)
sourceMetformin and Myo-Inositol: A Comparative Analysis.

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Source documents

  1. Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
  2. Metformin and Myo-Inositol: A Comparative Analysis.