evidence table

Milk Thistle Liver Enzyme Meta-Analysis Evidence Table

Structured evidence table for Milk Thistle Liver Enzyme Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Milk Thistle Liver Enzyme Meta-AnalysisConclusion Silymarin combined with lifestyle modifications is a safe and effective treatment option for reducing and normalizing liver enzyme levels in patients with NAFLD and associated metabolic syndrome.4Sukeepaisarnjaroen W (2026)Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
Milk Thistle Liver Enzyme Meta-AnalysisBackground Non-alcoholic fatty liver disease (NAFLD) has now become a major global health concern.4Sukeepaisarnjaroen W (2026)Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
Milk Thistle Liver Enzyme Meta-AnalysisLifestyle modifications are the first line of treatment; however, their effectiveness is often limited.4Sukeepaisarnjaroen W (2026)Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
Milk Thistle Liver Enzyme Meta-AnalysisSilymarin, extracted from the seeds of Silybum marianum (milk thistle), has been utilised in traditional medicine for many years and is recognised for its neuroprotective and hepatoprotective properties.4Sayyad M (2025)Silymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications.
Milk Thistle Liver Enzyme Meta-AnalysisExisting research reveals that silymarin has potent antioxidant and anti-inflammatory effects, coupled with anti-fibrotic, anti-carcinogenic, neuro-regenerative, and immunomodulatory actions, and has broad therapeutic relevance in both neurological and hepatic disorders, albeit with the drawback of low solubility.4Sayyad M (2025)Silymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications.
topicMilk Thistle Liver Enzyme Meta-Analysis
claimConclusion Silymarin combined with lifestyle modifications is a safe and effective treatment option for reducing and normalizing liver enzyme levels in patients with NAFLD and associated metabolic syndrome.
evidence level4
citationSukeepaisarnjaroen W (2026)
sourceEffectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
topicMilk Thistle Liver Enzyme Meta-Analysis
claimBackground Non-alcoholic fatty liver disease (NAFLD) has now become a major global health concern.
evidence level4
citationSukeepaisarnjaroen W (2026)
sourceEffectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
topicMilk Thistle Liver Enzyme Meta-Analysis
claimLifestyle modifications are the first line of treatment; however, their effectiveness is often limited.
evidence level4
citationSukeepaisarnjaroen W (2026)
sourceEffectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
topicMilk Thistle Liver Enzyme Meta-Analysis
claimSilymarin, extracted from the seeds of Silybum marianum (milk thistle), has been utilised in traditional medicine for many years and is recognised for its neuroprotective and hepatoprotective properties.
evidence level4
citationSayyad M (2025)
sourceSilymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications.
topicMilk Thistle Liver Enzyme Meta-Analysis
claimExisting research reveals that silymarin has potent antioxidant and anti-inflammatory effects, coupled with anti-fibrotic, anti-carcinogenic, neuro-regenerative, and immunomodulatory actions, and has broad therapeutic relevance in both neurological and hepatic disorders, albeit with the drawback of low solubility.
evidence level4
citationSayyad M (2025)
sourceSilymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications.

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Source documents

  1. Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.
  2. Silymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications.