topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimThis evidence supports the notion that these compounds may serve as a viable treatment option for OA.[,] 15 16 17 18 19 20 21 22 23 24 25 26 Collagen is a fibrous protein composed of peptides with a unique molecular structure that provides strength and elasticity.
evidence level2
citationGenç Ahmet Serhat (2025)
sourceEffect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimIn the present study, we hypothesized that collagen supplementation containing all these components could exert a beneficial impact on symptoms associated with OA.
evidence level2
citationGenç Ahmet Serhat (2025)
sourceEffect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimThe BBS is a scale developed to assess the risk of falls and loss of balance in patients.
evidence level2
citationGenç Ahmet Serhat (2025)
sourceEffect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimThis formulation stands out for its distinctive composition among collagen supplements.
evidence level2
citationGenç Ahmet Serhat (2025)
sourceEffect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimBy summarizing the current evidence and highlighting both clinical and biological mechanisms, this work aims to support evidence-based practice and stimulate further research into the versatile use of HA in oral health and regenerative therapies.
evidence level3
citationMalcangi Giuseppina (2025)
sourceRecent Use of Hyaluronic Acid in Dental Medicine
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimSeveral HA-interacting membrane receptors such as CD44, RHAMM, HARE and toll-like receptor 4/2 have been found to activate various signalling pathways modulating developmental activity, morphogenesis, tumour activity, cell migration, apoptosis, cell stimulation and inflammation [,,,,,,,,,].
evidence level3
citationMalcangi Giuseppina (2025)
sourceRecent Use of Hyaluronic Acid in Dental Medicine
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimA high molecular weight HA polymer > 1000 kDa can generate clustering at the cell membrane receptor with anti-apoptotic activity, whereas low molecular weight HA fragments can induce pro-inflammatory effects with increased presence of inflammatory cells and macrophages [,,,,,].
evidence level3
citationMalcangi Giuseppina (2025)
sourceRecent Use of Hyaluronic Acid in Dental Medicine
topicMethylsulfonylmethane Joint Comfort Randomized Trial
claimFigure 1 1 This article is intended for a broad audience, including dental professionals, researchers, clinicians, and healthcare providers interested in the applications of hyaluronic acid (HA) in dentistry.
evidence level3
citationMalcangi Giuseppina (2025)
sourceRecent Use of Hyaluronic Acid in Dental Medicine