topicMethylsulfonylmethane Exercise Recovery Randomized Trial
claimTemporomandibular disorders (TMDs) encompass a spectrum of musculoskeletal and joint conditions of the masticatory system that frequently lead to chronic pain, limited function, and reduced quality of life.
evidence level3
citationGazali M (2026)
sourceDiagnosis-based pathways for conservative and minimally invasive management of temporomandibular disorders: a scoping review.
topicMethylsulfonylmethane Exercise Recovery Randomized Trial
claimAlthough conservative and minimally invasive approaches are recommended as first-line therapies, their comparative efficacy remains unclear.This scoping review mapped evidence from randomized controlled trials (RCTs) published between 2015 and 2025 to identify diagnosis-based effective management pathways for TMDs.
evidence level3
citationGazali M (2026)
sourceDiagnosis-based pathways for conservative and minimally invasive management of temporomandibular disorders: a scoping review.
topicMethylsulfonylmethane Exercise Recovery Randomized Trial
claimOverall, the evidence from the past decade supports a diagnosis-driven, stepwise model that emphasizes conservative multimodal care as the cornerstone of TMD management.
evidence level3
citationGazali M (2026)
sourceDiagnosis-based pathways for conservative and minimally invasive management of temporomandibular disorders: a scoping review.
topicMethylsulfonylmethane Exercise Recovery Randomized Trial
claimVenous blood samples were collected prior to (PRE) the event, as well as 2 h and 4 h after the event to measure the expression of 700 mRNAs associated with generalized immune response.
evidence level4
citationMcFarlin BK (2025)
sourceUsing the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA.
topicMethylsulfonylmethane Exercise Recovery Randomized Trial
claimBackground: Long-duration aerobic exercise results in a similar, albeit transient rise and fall in oxidative stress and inflammation, making it a useful model to evaluate nutritional supplements targeting these physiological processes.
evidence level4
citationMcFarlin BK (2025)
sourceUsing the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA.
topicMethylsulfonylmethane Exercise Recovery Randomized Trial
claimObjective: To evaluate the impact of MSM supplementation on post-exercise immune response-related mRNA expression.
evidence level4
citationMcFarlin BK (2025)
sourceUsing the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA.