Quick Answer
Urolithin A Exercise Recovery Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Wukich and colleagues established that diabetes adversely affects outcomes across all orthopedic subspecialties, including increased surgical site infections, delayed wound healing, and impaired bone consolidation [].
Key Takeaways
- 01Wukich and colleagues established that diabetes adversely affects outcomes across all orthopedic subspecialties, including increased surgical site infections, delayed wound healing, and impaired bone consolidation []. [Santos Márcia da Silva (2026)]
- 02Meta-analytic evidence demonstrates that diabetic patients have an odds ratio of 2.11 for impaired fracture healing compared to non-diabetic individuals [], while tendinopathy prevalence is markedly elevated, with 27.5% of diabetic patients experiencing shoulder disorders compared to 5% in the general population [,]. [Santos Márcia da Silva (2026)]
- 03A notable 19-year follow-up study confirmed a persistent increased risk of tendon injury in patients with structured diabetes care. [Santos Márcia da Silva (2026)]
- 041 2 3 4 Type 2 diabetes mellitus (T2DM) has reached pandemic proportions, affecting over 537 million adults globally, with projections indicating 783 million by 2045 []. [Santos Márcia da Silva (2026)]
The current Migaku evidence database contains 1 reusable source document for Urolithin A Exercise Recovery Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts.
- Wukich and colleagues established that diabetes adversely affects outcomes across all orthopedic subspecialties, including increased surgical site infections, delayed wound healing, and impaired bone consolidation []. [Santos Márcia da Silva (2026); evidence level 4]
- Meta-analytic evidence demonstrates that diabetic patients have an odds ratio of 2.11 for impaired fracture healing compared to non-diabetic individuals [], while tendinopathy prevalence is markedly elevated, with 27.5% of diabetic patients experiencing shoulder disorders compared to 5% in the general population [,]. [Santos Márcia da Silva (2026); evidence level 4]
- A notable 19-year follow-up study confirmed a persistent increased risk of tendon injury in patients with structured diabetes care. [Santos Márcia da Silva (2026); evidence level 4]
- 1 2 3 4 Type 2 diabetes mellitus (T2DM) has reached pandemic proportions, affecting over 537 million adults globally, with projections indicating 783 million by 2045 []. [Santos Márcia da Silva (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources