Structured evidence table for Methylfolate Mood Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Methylfolate Mood Randomized Trial | Introduction Emerging real-world evidence suggests that folate supplementation may reduce suicidal ideation and behavior. | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Methylfolate Mood Randomized Trial | One within-person cohort study found a 44% lower hazard of suicide-related emergency or hospital visits after treatment with folic acid (hazard ratio = 0.56) (and none in a parallel analysis of vitamin B12). | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Methylfolate Mood Randomized Trial | One case-control study of patients with a history of suicidal behavior and ideation found lower suicidal ideation questionnaire scores with folinic acid ( P Discussion Evidence linking folate supplementation to reduced suicidal behavior is promising but limited by heterogeneity in design, sample size, folate formulation, and outcome measurement. | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Methylfolate Mood Randomized Trial | We conducted a scoping review to evaluate current hypothesis-testing literature on folate supplementation and outcomes related to suicide. | 3 | Noel C (2026) | The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review. |
| Methylfolate Mood Randomized Trial | A comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations []. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Methylfolate Mood Randomized Trial | 6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Methylfolate Mood Randomized Trial | When methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways []. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Methylfolate Mood Randomized Trial | 1 2 Depression and anxiety disorders are leading contributors to global disability. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
Source documents