Structured evidence table for Melissa Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Melissa Sleep Randomized Trial | In the principal clinical trial, 3 weeks of Melissa phospholipids' supplementation was associated with significant improvements in sleep quality and mood outcomes. | 4 | Mazzola G (2026) | Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based <i>Melissa officinalis</i> supplement: a secondary analysis in a subpopulation. |
| Melissa Sleep Randomized Trial | Background Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, as indicated by altered salivary cortisol secretion, has been linked to poor sleep quality, mood disturbances, and emotional distress. | 4 | Mazzola G (2026) | Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based <i>Melissa officinalis</i> supplement: a secondary analysis in a subpopulation. |
| Melissa Sleep Randomized Trial | Historical use of medicinal plants was a result of cumulative trial and error experience and the transmission of traditional knowledge between generations, which later inspired systematic efforts to turn empirical claims into evidence-based arguments []. | 4 | Cîmpeanu Ioan-Alexandru (2026) | Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies |
| Melissa Sleep Randomized Trial | Also, standardization and phytochemical reporting is the preferred method for interpreting the evidence base across Lamiaceae, as its composition is influenced by genetics, geography, cultivation, and post-harvest handling [,]. | 4 | Cîmpeanu Ioan-Alexandru (2026) | Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies |
| Melissa Sleep Randomized Trial | Accordingly, the present review mapsfrom botanical and phytochemical fundamentals through recent preclinical advances and available clinical evidence, with emphasis on endpoints that best support translation and reproducibility across study types. | 4 | Cîmpeanu Ioan-Alexandru (2026) | Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies |
| Melissa Sleep Randomized Trial | 1 2 2 1 3 4 1 2 4 5 Traditional healing systems and contemporary natural products research still depend on medicinal and aromatic plants, which continue to provide structurally diverse bioactive compounds with broad therapeutic potential [,]. | 4 | Cîmpeanu Ioan-Alexandru (2026) | Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies |
Source documents