Structured evidence table for Manganese Bone Health Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Manganese Bone Health Meta-Analysis | In bone development, it was found that Mn is also necessary for the functioning of key enzymes, that is, it has a high ability to protect cells from damage by free radicals []. | 3 | Taskozhina Gulaim (2024) | The Manganese–Bone Connection: Investigating the Role of Manganese in Bone Health |
| Manganese Bone Health Meta-Analysis | 2+ 3+ 2+ 3+ 2+ 2+ 3+ 2+ 3+ − 2+ 3+ 19 20 21 22 23 2 2 2 Although Mn has many oxidation states, the two most common forms found in the human body are Mnand Mn[]. | 3 | Taskozhina Gulaim (2024) | The Manganese–Bone Connection: Investigating the Role of Manganese in Bone Health |
| Manganese Bone Health Meta-Analysis | Collagen types II and X are present in the growth plate bone, and they are proposed to participate in bone formation, but they are mainly found in cartilage [,]. | 3 | Taskozhina Gulaim (2024) | The Manganese–Bone Connection: Investigating the Role of Manganese in Bone Health |
| Manganese Bone Health Meta-Analysis | 1 2 3 4 5 6 7 8 9 The main support function in the human body is provided by the structural integrity of bones []. | 3 | Taskozhina Gulaim (2024) | The Manganese–Bone Connection: Investigating the Role of Manganese in Bone Health |
| Manganese Bone Health Meta-Analysis | Although testosterone (T) is the principal circulating androgen, evidence from both genetic models and clinical studies of men with aromatase deficiency or ER mutations indicates that estrogens, generated through peripheral aromatization of testosterone, play a dominant role in regulating bone metabolism and maintaining bone mass []. | 4 | Rył Aleksandra (2026) | Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis |
| Manganese Bone Health Meta-Analysis | While testosterone is essential for muscle mass and joint loading distribution, high genetically predicted levels of sex steroids, particularly testosterone, have been paradoxically linked to an increased risk of developing hip and knee osteoarthritis in men, as demonstrated by recent Mendelian randomization studies []. | 4 | Rył Aleksandra (2026) | Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis |
| Manganese Bone Health Meta-Analysis | In contrast, local ERdensity exhibited a pronounced negative correlation with BMI (rs = −0.442,= 0.002), indicating that increased adiposity is linked to a downregulation of estrogenic pathways within the joint microenvironment. | 4 | Rył Aleksandra (2026) | Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis |
| Manganese Bone Health Meta-Analysis | 1 2 3 The maintenance of bone tissue homeostasis in men is a multifactorial process in which the regulation of steroid receptor-dependent signaling pathways—androgen receptor (AR) and estrogen receptors (ERα and ERβ)—plays a central role. | 4 | Rył Aleksandra (2026) | Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis |
Source documents