evidence table
Magnesium Threonate Cognition Randomized Trial Evidence Table
Structured evidence table for Magnesium Threonate Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Magnesium Threonate Cognition Randomized Trial | Results Compared to the placebo, Magtein ® was associated with greater improvements in overall cognitive performance as measured by the NIH Total Cognition Composite ( p = 0.043), with larger treatment effects on working and episodic memory. | 2 | Lopresti AL (2026) | The effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. |
| Magnesium Threonate Cognition Randomized Trial | Based on data from the sleep tracking ring, there were no group differences in sleep outcomes, although there was a greater reduction in HR ( p = 0.030) and an increase in HRV ( p = 0.036), a physiological marker of stress reduction and improved autonomic balance. | 2 | Lopresti AL (2026) | The effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. |
| Magnesium Threonate Cognition Randomized Trial | Conclusion The results from this study suggest Magtein ® supplementation for 6 weeks improves overall cognition, cognitive age, working memory, reaction time, HR, HRV, and some subjective, but not objective measures of sleep in healthy adults with self-reported dissatisfied sleep. | 2 | Lopresti AL (2026) | The effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. |
| Magnesium Threonate Cognition Randomized Trial | The purpose of this two-arm, 6-week, parallel-group, randomised, double-blind, placebo-controlled trial was to examine the effects of magnesium L-threonate (Magtein ® ) supplementation on cognitive performance, cognitive age, sleep quality, and selected physiological indicators in adults. | 2 | Lopresti AL (2026) | The effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. |
| Magnesium Threonate Cognition Randomized Trial | Current research suggests that magnesium deficiency is associated with the development of depression, as magnesium influences glutamatergic and GABAergic neurotransmission, as well as the activity of the hypothalamic-pituitary-adrenal (HPA) axis, both of which play critical roles in stress responses and mood regulation. | 3 | Varga P (2025) | The Role of Magnesium in Depression, Migraine, Alzheimer's Disease, and Cognitive Health: A Comprehensive Review. |
| Magnesium Threonate Cognition Randomized Trial | Magnesium is an essential mineral involved in hundreds of biochemical reactions, with particular relevance to maintaining neural homeostasis, modulating neurotransmitter systems, and regulating inflammatory and oxidative stress mechanisms. | 3 | Varga P (2025) | The Role of Magnesium in Depression, Migraine, Alzheimer's Disease, and Cognitive Health: A Comprehensive Review. |
| Magnesium Threonate Cognition Randomized Trial | This comprehensive review aims to evaluate the potential role of magnesium in the pathophysiology and treatment of three prevalent neurological and psychiatric disorders-depression, migraine, and Alzheimer's disease-as well as its broader implications for cognitive health. | 3 | Varga P (2025) | The Role of Magnesium in Depression, Migraine, Alzheimer's Disease, and Cognitive Health: A Comprehensive Review. |
Source documents