evidence table

Magnesium Stress Randomized Trial Evidence Table

Structured evidence table for Magnesium Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Magnesium Stress Randomized TrialThis review synthesizes current evidence and provides context for an ongoing cluster-randomized trial that is testing whether a center-wide dialysate magnesium concentration of 0.75 mmol/L, versus ≤0.50 mmol/L, delivered as a policy and sustained for up to four years, reduces the risk of major cardiovascular-related hospitalizations.4Tannar B (2026)Effects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
Magnesium Stress Randomized TrialSystematic reviews and meta-analyses show that hypomagnesemia is associated with higher risks of cardiovascular events and all-cause mortality in hemodialysis.4Tannar B (2026)Effects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
Magnesium Stress Randomized TrialGiven encouraging but predominantly surrogate-based evidence, adequately powered randomized trials are warranted.4Tannar B (2026)Effects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
Magnesium Stress Randomized TrialPurpose of review Cardiovascular disease (CVD) accounts for nearly half of deaths among people receiving maintenance hemodialysis.4Tannar B (2026)Effects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
Magnesium Stress Randomized TrialAlthough Mg is frequently discussed as an analgesic supplement, emerging evidence suggests that it acts as a neurovascular-metabolic modulator.4Yoon Y (2026)Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
Magnesium Stress Randomized TrialLow magnesium status has been associated with endothelial dysfunction, atherosclerotic burden, impaired microcirculatory function, and overlapping ischemic and neuropathic pain phenotypes, although direct causal clinical evidence remains limited.4Yoon Y (2026)Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
Magnesium Stress Randomized TrialThe evidence is strongest for mechanistic vascular and neuropathic pathways, whereas direct clinical evidence for magnesium supplementation in PAD-related ischemic limb pain remains limited.4Yoon Y (2026)Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
Magnesium Stress Randomized TrialMagnesium (Mg) is an essential divalent cation involved in more than 600 enzymatic reactions and plays a fundamental role in vascular, metabolic, and neural homeostasis.4Yoon Y (2026)Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
topicMagnesium Stress Randomized Trial
claimThis review synthesizes current evidence and provides context for an ongoing cluster-randomized trial that is testing whether a center-wide dialysate magnesium concentration of 0.75 mmol/L, versus ≤0.50 mmol/L, delivered as a policy and sustained for up to four years, reduces the risk of major cardiovascular-related hospitalizations.
evidence level4
citationTannar B (2026)
sourceEffects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
topicMagnesium Stress Randomized Trial
claimSystematic reviews and meta-analyses show that hypomagnesemia is associated with higher risks of cardiovascular events and all-cause mortality in hemodialysis.
evidence level4
citationTannar B (2026)
sourceEffects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
topicMagnesium Stress Randomized Trial
claimGiven encouraging but predominantly surrogate-based evidence, adequately powered randomized trials are warranted.
evidence level4
citationTannar B (2026)
sourceEffects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
topicMagnesium Stress Randomized Trial
claimPurpose of review Cardiovascular disease (CVD) accounts for nearly half of deaths among people receiving maintenance hemodialysis.
evidence level4
citationTannar B (2026)
sourceEffects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
topicMagnesium Stress Randomized Trial
claimAlthough Mg is frequently discussed as an analgesic supplement, emerging evidence suggests that it acts as a neurovascular-metabolic modulator.
evidence level4
citationYoon Y (2026)
sourceMagnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
topicMagnesium Stress Randomized Trial
claimLow magnesium status has been associated with endothelial dysfunction, atherosclerotic burden, impaired microcirculatory function, and overlapping ischemic and neuropathic pain phenotypes, although direct causal clinical evidence remains limited.
evidence level4
citationYoon Y (2026)
sourceMagnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
topicMagnesium Stress Randomized Trial
claimThe evidence is strongest for mechanistic vascular and neuropathic pathways, whereas direct clinical evidence for magnesium supplementation in PAD-related ischemic limb pain remains limited.
evidence level4
citationYoon Y (2026)
sourceMagnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
topicMagnesium Stress Randomized Trial
claimMagnesium (Mg) is an essential divalent cation involved in more than 600 enzymatic reactions and plays a fundamental role in vascular, metabolic, and neural homeostasis.
evidence level4
citationYoon Y (2026)
sourceMagnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.

Learn next

Related evidence and supplement guides

SupplementMagnesium ThreonateThe only magnesium form clinically shown to cross the blood-brain barrier — for cognitive health...GuideL-theanine Stress Randomized Trial: What the Evidence SaysL-theanine Stress Randomized Trial has 1 source documents in the current Migaku evidence databas...GuideQuercetin Stress Randomized Trial: What the Evidence SaysQuercetin Stress Randomized Trial has 2 source documents in the current Migaku evidence database...GuideCocoa Flavanol Stress Randomized Trial: What the Evidence SaysCocoa Flavanol Stress Randomized Trial has 2 source documents in the current Migaku evidence dat...GuideMagnesium Malate Fatigue Randomized Trial: What the Evidence SaysMagnesium Malate Fatigue Randomized Trial has 2 source documents in the current Migaku evidence...CompareMagnesium Glycinate vs 其他镁形式（氧化镁、柠檬酸镁等）市场上有许多不同的镁补充剂形式，但不是所有形式都相等。CompareMagnesium L-Threonate vs Magnesium GlycinateComparing Magnesium L-Threonate and Magnesium Glycinate for sleep reveals two distinct mechanism...CompareMagnesium Glycinate vs Magnesium CitrateBoth popular magnesium forms support sleep and relaxation, but differ in absorption rate and dig...

Source documents

  1. Effects of Increasing the Concentration of Dialysate Magnesium on Cardiovascular Health: A Narrative Review.
  2. Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.