topicMagnesium Perceived Stress Randomized Trial
claimAs medical doctors and clinical researchers, we inhabit a world of evidence-based practice.
evidence level3
citationSheldon Rocco (2026)
sourceConsumer-Relevant Endpoints in Nutritional Supplement Research: A Case of Multivitamin and Mineral Supplements
topicMagnesium Perceived Stress Randomized Trial
claim1 2 3 The Physicians’ Health Study II (PHS-II) [], a large RCT enrolling 14,641 male physicians, found that long-term daily MVM use had no significant effect on major cardiovascular events or all-cause mortality.
evidence level3
citationSheldon Rocco (2026)
sourceConsumer-Relevant Endpoints in Nutritional Supplement Research: A Case of Multivitamin and Mineral Supplements
topicMagnesium Perceived Stress Randomized Trial
claimThe COcoa Supplement and Multivitamin Outcomes Study (COSMOS) [], which randomly assigned >21,442 older males and females, also found that MVM supplementation did not reduce the risk of cardiovascular disease (CVD) or cancer.
evidence level3
citationSheldon Rocco (2026)
sourceConsumer-Relevant Endpoints in Nutritional Supplement Research: A Case of Multivitamin and Mineral Supplements
topicMagnesium Perceived Stress Randomized Trial
claimWe are guided by large-scale, randomized, double-blind, placebo-controlled trials [randomized controlled trial (RCTs)] as the reference standard of our profession.
evidence level3
citationSheldon Rocco (2026)
sourceConsumer-Relevant Endpoints in Nutritional Supplement Research: A Case of Multivitamin and Mineral Supplements
topicMagnesium Perceived Stress Randomized Trial
claimThis study presents evidence that functional nutrition serves as a nonpharmacological method for supporting cognitive health.
evidence level4
citationTultabayev M (2026)
sourceFunctional nutrition: a non-pharmacological approach to supporting cognitive Health.
topicMagnesium Perceived Stress Randomized Trial
claimSpecific nutrients and dietary patterns known for their supportive effects on cognitive ability and neuroprotection, such as omega-3 fatty acids, antioxidants (vitamins C and E), polyphenols, magnesium, B vitamins, and flavonoid-rich foods, are proposed.
evidence level4
citationTultabayev M (2026)
sourceFunctional nutrition: a non-pharmacological approach to supporting cognitive Health.