topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claimBoth chronic stress and poor sleep are associated with decrements in health, well-being, and daily occupational performance [,].
evidence level2
citationMastrofini Gianna F. (2026)
sourceModulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claimAs a result, chronic stress and sleep deficiencies pose a major public health concern.
evidence level2
citationMastrofini Gianna F. (2026)
sourceModulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claimAlthough dietary magnesium is associated with better sleep quality [], research on magnesium supplementation has yielded mixed results, likely due to heterogeneity in doses, populations studied, and formulations [,].
evidence level2
citationMastrofini Gianna F. (2026)
sourceModulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claim1 2 3 4 5 It has been suggested that approximately half the global population experiences elevated levels of stress, attributed to workplace and economic stressors, manifested as depression and/or anxiety [].
evidence level2
citationMastrofini Gianna F. (2026)
sourceModulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claimHypomagnesemia has been associated with refractory hypokalemia, hypocalcemia, and metabolic alkalosis, and these disturbances improve only with optimization of magnesium status.
evidence level3
citationSankararaman Senthilkumar (2026)
sourceMagnesium: Hype and Health Benefits
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claimExperts recommend a combination of serum magnesium, urinary magnesium, and dietary magnesium intake as the best way to determine magnesium status compared to using serum levels alone [].
evidence level3
citationSankararaman Senthilkumar (2026)
sourceMagnesium: Hype and Health Benefits
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claimIn this article, we evaluated both evidence-based claims and also reviewed the purported health benefits of magnesium on various systems and disorders (Fig.).
evidence level3
citationSankararaman Senthilkumar (2026)
sourceMagnesium: Hype and Health Benefits
topicMagnesium L-Threonate Cognitive Performance Randomized Trial
claim1 2 3 4 5 3 4 6 3 5 7 Magnesium is the second most prevalent intracellular cation (after potassium) and overall fourth most abundant cation in the body (after sodium, potassium, and calcium) [].
evidence level3
citationSankararaman Senthilkumar (2026)
sourceMagnesium: Hype and Health Benefits