topicMagnesium L Threonate Cognition Randomized Trial
claimResults Compared to the placebo, Magtein ® was associated with greater improvements in overall cognitive performance as measured by the NIH Total Cognition Composite ( p = 0.043), with larger treatment effects on working and episodic memory.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium L Threonate Cognition Randomized Trial
claimBased on data from the sleep tracking ring, there were no group differences in sleep outcomes, although there was a greater reduction in HR ( p = 0.030) and an increase in HRV ( p = 0.036), a physiological marker of stress reduction and improved autonomic balance.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium L Threonate Cognition Randomized Trial
claimConclusion The results from this study suggest Magtein ® supplementation for 6 weeks improves overall cognition, cognitive age, working memory, reaction time, HR, HRV, and some subjective, but not objective measures of sleep in healthy adults with self-reported dissatisfied sleep.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium L Threonate Cognition Randomized Trial
claimThe purpose of this two-arm, 6-week, parallel-group, randomised, double-blind, placebo-controlled trial was to examine the effects of magnesium L-threonate (Magtein ® ) supplementation on cognitive performance, cognitive age, sleep quality, and selected physiological indicators in adults.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium L Threonate Cognition Randomized Trial
claimEvidence that intestinal dysbiosis plays a role in the pathogenesis of diseases of the central nervous system (CNS) is increasing (Alsegiani and Shah, 2022; Chidambaram et al., 2022b).
evidence level4
citationLiao Wang (2024)
sourceMagnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis
topicMagnesium L Threonate Cognition Randomized Trial
claimThe lipopolysaccharides found in amyloid plaques and the blood vessels surrounding them in the brains of patients with AD are also pro-inflammatory compounds.
evidence level4
citationLiao Wang (2024)
sourceMagnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis
topicMagnesium L Threonate Cognition Randomized Trial
claimThese patients exhibited reduced gut microbial diversity, with overrepresention of some bacteria and greatly reduced abundance of others (Marizzoni et al., 2020; Trejo-Castro et al., 2022).
evidence level4
citationLiao Wang (2024)
sourceMagnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis
topicMagnesium L Threonate Cognition Randomized Trial
claimAlzheimer’s disease (AD) is one of the most serious age-related diseases and, along with cardiovascular diseases and tumors, is a leading cause of death (Tiwari et al., 2019).
evidence level4
citationLiao Wang (2024)
sourceMagnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis