topicMaca Sleep Randomized Trial
claimIt is associated with increased risk of stroke, heart failure, hospitalization, and mortality, placing a substantial clinical and economic burden on healthcare systems [,].
evidence level4
citationSokolova Emma (2026)
sourceIntegrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model
topicMaca Sleep Randomized Trial
claimFor example, studies suggest that up to 30–40% of patients with AF report cognitive complaints or sleep disturbances, both of which are associated with reduced quality of life and increased healthcare utilization [,,,].
evidence level4
citationSokolova Emma (2026)
sourceIntegrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model
topicMaca Sleep Randomized Trial
claimAs a result, their potential to inform treatment strategies, guide resource allocation, and improve health system performance remains underused.
evidence level4
citationSokolova Emma (2026)
sourceIntegrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model
topicMaca Sleep Randomized Trial
claim1 2 3 4 5 6 Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide, affecting an estimated 37–40 million individuals [,].
evidence level4
citationSokolova Emma (2026)
sourceIntegrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model
topicMaca Sleep Randomized Trial
claimBy synthesizing molecular evidence from the BDNF/TrkB/CREB signaling axis and the Nrf2/NF-κB homeostatic switch, we demonstrate that this multi-target strategy offers a more robust path to neuronal resilience than traditional single-target approaches.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Sleep Randomized Trial
claimThis narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Sleep Randomized Trial
claimWe illustrate how the synergistic interplay between a 'core triad' composed of Hericium erinaceus , Bacopa monnieri , and L-Theanine targets these pillars with high specificity.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.