Maca Mood Randomized Trial Evidence Table

Structured evidence table for Maca Mood Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Maca Mood Randomized TrialIn general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Maca Mood Randomized TrialThe analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls.1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Maca Mood Randomized TrialSaffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72).1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Maca Mood Randomized TrialIncidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022.1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Maca Mood Randomized TrialBy synthesizing molecular evidence from the BDNF/TrkB/CREB signaling axis and the Nrf2/NF-κB homeostatic switch, we demonstrate that this multi-target strategy offers a more robust path to neuronal resilience than traditional single-target approaches.4Cipriano GL (2026)Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
Maca Mood Randomized TrialThis narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection.4Cipriano GL (2026)Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
Maca Mood Randomized TrialWe illustrate how the synergistic interplay between a 'core triad' composed of Hericium erinaceus , Bacopa monnieri , and L-Theanine targets these pillars with high specificity.4Cipriano GL (2026)Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Mood Randomized Trial
claimIn general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Mood Randomized Trial
claimThe analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Mood Randomized Trial
claimSaffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72).
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Mood Randomized Trial
claimIncidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Mood Randomized Trial
claimBy synthesizing molecular evidence from the BDNF/TrkB/CREB signaling axis and the Nrf2/NF-κB homeostatic switch, we demonstrate that this multi-target strategy offers a more robust path to neuronal resilience than traditional single-target approaches.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Mood Randomized Trial
claimThis narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Mood Randomized Trial
claimWe illustrate how the synergistic interplay between a 'core triad' composed of Hericium erinaceus , Bacopa monnieri , and L-Theanine targets these pillars with high specificity.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.

Source documents

  1. Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
  2. Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.