topicMaca Fatigue Meta-Analysis
claimIn general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Meta-Analysis
claimThe analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Meta-Analysis
claimSaffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72).
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Meta-Analysis
claimIncidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Meta-Analysis
claimExercise-induced fatigue (EIF) refers to a reduced capacity to sustain a specified level or intensity of physical activity and is generally regarded as a physiological warning signal following excessive exercise rather than a pathological state.
evidence level4
citationYang Y (2026)
sourceNutritional Interventions and Acupuncture-Based Strategies for Exercise-Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives.
topicMaca Fatigue Meta-Analysis
claimIn this review, we synthesize evidence from nutritional interventions and acupuncture-based strategies and outline a conceptual mechanistic framework relevant to EIF management.
evidence level4
citationYang Y (2026)
sourceNutritional Interventions and Acupuncture-Based Strategies for Exercise-Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives.
topicMaca Fatigue Meta-Analysis
claimAcupuncture, electroacupuncture (EA), and transcutaneous electrical acupoint stimulation (TEAS) have been associated with regulation of autonomic function and hypothalamic-pituitary-adrenal axis activity, modulation of pain and affective circuits, and changes in skeletal muscle perfusion, mitochondrial function, and antioxidant and anti-inflammatory signaling.
evidence level4
citationYang Y (2026)
sourceNutritional Interventions and Acupuncture-Based Strategies for Exercise-Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives.
topicMaca Fatigue Meta-Analysis
claimIt involves peripheral disturbances related to energy depletion, metabolite accumulation, oxidative stress, inflammation, and mitochondrial dysfunction, together with central changes involving neuroendocrine networks and the gut-brain axis.
evidence level4
citationYang Y (2026)
sourceNutritional Interventions and Acupuncture-Based Strategies for Exercise-Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives.