Structured evidence table for Lutein Supplementation Macular Health Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Lutein Supplementation Macular Health Meta-Analysis | Major vision-threatening conditions such as glaucoma, cataracts, age-related macular degeneration (AMD), diabetic retinopathy (DR), uveitis, retinal detachment, etc., contribute significantly to functional disability and reduced quality of life [,]. | 4 | De Silva Sandun (2026) | Beneficial Effects of Natural Bioactive Compounds on Eye Health: A Narrative Review |
| Lutein Supplementation Macular Health Meta-Analysis | Oxidative stress, chronic inflammation, mitochondrial dysfunction, dysregulated angiogenesis and metabolic imbalance are highly associated with the molecular-level pathogenesis of these ocular diseases. | 4 | De Silva Sandun (2026) | Beneficial Effects of Natural Bioactive Compounds on Eye Health: A Narrative Review |
| Lutein Supplementation Macular Health Meta-Analysis | Furthermore, bioavailability and therapeutic potential are increased by synergistic interactions among bioactives in whole extracts and improvements in delivery systems (e.g., nano-formulations). | 4 | De Silva Sandun (2026) | Beneficial Effects of Natural Bioactive Compounds on Eye Health: A Narrative Review |
| Lutein Supplementation Macular Health Meta-Analysis | 1 2 2 3 4 5 6 Visual impairment is a major global health problem with an increasing prevalence due to population ageing, higher incidence of metabolic diseases such as diabetes, and prolonged exposure to digital devices. | 4 | De Silva Sandun (2026) | Beneficial Effects of Natural Bioactive Compounds on Eye Health: A Narrative Review |
| Lutein Supplementation Macular Health Meta-Analysis | Although the prevalence of AMD increases with factors such as age, smoking, and sun exposure, these alone do not fully explain individual risk. | 4 | Istanaksai A (2026) | The Effect of Nutrition on Dry Age-Related Macular Degeneration: A Systematic Narrative Review of Evidence and Clinical Implications. |
| Lutein Supplementation Macular Health Meta-Analysis | Age-related macular degeneration (AMD) is a progressive retinal condition characterised by degeneration of the macula, leading to central vision loss. | 4 | Istanaksai A (2026) | The Effect of Nutrition on Dry Age-Related Macular Degeneration: A Systematic Narrative Review of Evidence and Clinical Implications. |
| Lutein Supplementation Macular Health Meta-Analysis | Whilst the underlying mechanism of AMD is not fully understood, oxidative stress is believed to be the main driving force behind retinal damage. | 4 | Istanaksai A (2026) | The Effect of Nutrition on Dry Age-Related Macular Degeneration: A Systematic Narrative Review of Evidence and Clinical Implications. |
Source documents