topicLion'S Mane Cognition Randomized Trial
claimHowever, when analysing individual tests, participants exhibited improved performance on the pegboard test at 90 minutes following a single dose of H.
evidence level2
citationSurendran G (2025)
sourceAcute effects of a standardised extract of <i>Hericium erinaceus</i> (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.
topicLion'S Mane Cognition Randomized Trial
claimIntroduction Animal studies have suggested that Lion's Mane mushroom [ Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones.
evidence level2
citationSurendran G (2025)
sourceAcute effects of a standardised extract of <i>Hericium erinaceus</i> (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.
topicLion'S Mane Cognition Randomized Trial
claimHowever, despite being an ingredient used both culinarily and therapeutically in the East, and more and more commonly in the West, limited research has focused on the immediate effects of H.
evidence level2
citationSurendran G (2025)
sourceAcute effects of a standardised extract of <i>Hericium erinaceus</i> (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.
topicLion'S Mane Cognition Randomized Trial
claimFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Randomized Trial
claimThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Randomized Trial
claimIt should be noted that the present work consists of a review and not a dosing guideline.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Randomized Trial
claim1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Randomized Trial
claimThe theory that AD may start many decades before symptoms develop should now be adjusted to include the new reality that AD may, in fact, begin in childhood in the many highly polluted areas of the globe, which essentially puts hundreds of millions more people at increased risk.
evidence level3
citationKhalsa Dharma Singh (2025)
sourceAir pollution and Alzheimer's disease prevention: The science and a prevention plan
topicLion'S Mane Cognition Randomized Trial
claimSecondly, a plan to prevent pathological changes and reduce the risk of AD and other neurodegenerative disorders will be presented.
evidence level3
citationKhalsa Dharma Singh (2025)
sourceAir pollution and Alzheimer's disease prevention: The science and a prevention plan
topicLion'S Mane Cognition Randomized Trial
claimfound a 95% increase in AD risk with higher levels of PM 2.5.Building on this Zhang et al.
evidence level3
citationKhalsa Dharma Singh (2025)
sourceAir pollution and Alzheimer's disease prevention: The science and a prevention plan
topicLion'S Mane Cognition Randomized Trial
claim1 An 11-year-old boy tragically lost his life after being struck by a vehicle while crossing the street in Mexico City, one of the most polluted places on earth.
evidence level3
citationKhalsa Dharma Singh (2025)
sourceAir pollution and Alzheimer's disease prevention: The science and a prevention plan