topicLemon Balm Sleep Quality Randomized Trial
claimHistorical use of medicinal plants was a result of cumulative trial and error experience and the transmission of traditional knowledge between generations, which later inspired systematic efforts to turn empirical claims into evidence-based arguments [].
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicLemon Balm Sleep Quality Randomized Trial
claimAlso, standardization and phytochemical reporting is the preferred method for interpreting the evidence base across Lamiaceae, as its composition is influenced by genetics, geography, cultivation, and post-harvest handling [,].
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicLemon Balm Sleep Quality Randomized Trial
claimAccordingly, the present review mapsfrom botanical and phytochemical fundamentals through recent preclinical advances and available clinical evidence, with emphasis on endpoints that best support translation and reproducibility across study types.
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicLemon Balm Sleep Quality Randomized Trial
claim1 2 2 1 3 4 1 2 4 5 Traditional healing systems and contemporary natural products research still depend on medicinal and aromatic plants, which continue to provide structurally diverse bioactive compounds with broad therapeutic potential [,].
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicLemon Balm Sleep Quality Randomized Trial
claimFor cognition, studies have shown that the plant improved cognitive performance and mood.
evidence level4
citationOliveira MVB (2025)
sourceUnraveling the Effects of <i>Melissa officinalis</i> L. on Cognition and Sleep Quality: A Narrative Review.
topicLemon Balm Sleep Quality Randomized Trial
claimIn elderly individuals with mild cognitive impairment or early Alzheimer's disease, extracts standardized in rosmarinic acid stabilized cognitive functions and reduced neuropsychiatric symptoms such as agitation.
evidence level4
citationOliveira MVB (2025)
sourceUnraveling the Effects of <i>Melissa officinalis</i> L. on Cognition and Sleep Quality: A Narrative Review.
topicLemon Balm Sleep Quality Randomized Trial
claimRegarding sleep, a combination of lemon balm and valerian significantly improved sleep quality in postmenopausal women.
evidence level4
citationOliveira MVB (2025)
sourceUnraveling the Effects of <i>Melissa officinalis</i> L. on Cognition and Sleep Quality: A Narrative Review.
topicLemon Balm Sleep Quality Randomized Trial
claimThe aging process is closely linked to cognitive decline, and numerous studies have demonstrated a decrease in both the quality and quantity of sleep in the general population.
evidence level4
citationOliveira MVB (2025)
sourceUnraveling the Effects of <i>Melissa officinalis</i> L. on Cognition and Sleep Quality: A Narrative Review.