Structured evidence table for Lactoferrin Immune Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Lactoferrin Immune Meta-Analysis | These peptides have been associated with immune regulation, anti-inflammatory, and antimicrobial properties [,], possibly modulating the gut microbiome [] and exhibiting systemic activity to mitigate microbial infections []. | 4 | Kaplan Nicole (2026) | The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health |
| Lactoferrin Immune Meta-Analysis | In a clinical study, lactoferrin supplementation has been linked to a pronounced increase in circulating neutrophil precursors, and an associated reduction in TNF-α and IL-6 production []. | 4 | Kaplan Nicole (2026) | The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health |
| Lactoferrin Immune Meta-Analysis | Although the mechanisms described here are associated with direct immune system regulation, lactoferrin also works through biochemical and cellular mechanisms that make it relevant for protection against environmental stressors such as pathogens and UV radiation [,], making it particularly relevant for hair and skin applications. | 4 | Kaplan Nicole (2026) | The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health |
| Lactoferrin Immune Meta-Analysis | 1 1 2 3 4 1 4 Lactoferrin is a multifunctional, iron-binding glycoprotein that has protective and tissue healing capacities throughout the life of an organism []. | 4 | Kaplan Nicole (2026) | The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health |
| Lactoferrin Immune Meta-Analysis | The PICOS question was: 'Are lactoferrin levels different between individuals with periodontitis and periodontally healthy controls, and are these levels associated with disease severity and established clinical periodontal indicators, supporting their role as diagnostic or prognostic biomarkers for periodontitis?'. | 4 | Patil GV (2026) | Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker. |
| Lactoferrin Immune Meta-Analysis | Egger's regression test produced a t-statistic of -0.646 (P=0.529), reflecting a lack of significant evidence for publication bias. | 4 | Patil GV (2026) | Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker. |
| Lactoferrin Immune Meta-Analysis | In conclusion, lactoferrin showed potential as a biomarker for periodontal disease, with elevated levels consistently linked to its presence and disease severity. | 4 | Patil GV (2026) | Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker. |
| Lactoferrin Immune Meta-Analysis | The present systematic review and meta-analysis assessed the clinical utility of lactoferrin as a biomarker for periodontitis by evaluating its association with established periodontal parameters, including probing pocket depth (PPD), clinical attachment loss (CAL) and gingival index (GI). | 4 | Patil GV (2026) | Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker. |
Source documents