topicL-Ornithine Sleep Quality Randomized Trial
claimAlthough L-ornithine is contained in various foods, the amount is usually small.Recently, studies have shown that orally administered L-ornithine reduced the stress response in animals.From these findings, we speculated that L-ornithine may play a role in the relieve of stress and improve sleep and fatigue symptoms in humans.
evidence level2
citationMiyake M (2014)
sourceRandomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
topicL-Ornithine Sleep Quality Randomized Trial
claimAlso, anger was reduced and perceived sleep quality was improved in the L-ornithine group.
evidence level2
citationMiyake M (2014)
sourceRandomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
topicL-Ornithine Sleep Quality Randomized Trial
claimConclusion L-ornithine supplementation has the potential to relieve stress and improve sleep quality related to fatigue, both objectively and subjectively.
evidence level2
citationMiyake M (2014)
sourceRandomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
topicL-Ornithine Sleep Quality Randomized Trial
claimThrough a randomised, double-blind, placebo-controlled clinical study, we asked if L-ornithine could be beneficial to stress and sleep in healthy workers.
evidence level2
citationMiyake M (2014)
sourceRandomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
topicL-Ornithine Sleep Quality Randomized Trial
claimThis narrative review discusses the burden of HE, precipitating risk factors, and key clinical considerations for reducing the risk of OHE recurrence in adults with cirrhosis.
evidence level4
citationPyrsopoulos Nikolaos T. (2026)
sourceReducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review
topicL-Ornithine Sleep Quality Randomized Trial
claimP P P P P P 7 The economic impact and loss of independence resulting from cognitive impairment and reduced functional capacity can also contribute to the burden of disease in both patients and their caregivers.
evidence level4
citationPyrsopoulos Nikolaos T. (2026)
sourceReducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review
topicL-Ornithine Sleep Quality Randomized Trial
claim17 18 Recurrence of HE episodes may result in persistent cognitive impairment, with a potential for residual deficits, even after perceived clinical resolution of symptoms.
evidence level4
citationPyrsopoulos Nikolaos T. (2026)
sourceReducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review
topicL-Ornithine Sleep Quality Randomized Trial
claimFor this narrative review, a PubMed and Google Scholar search of English-language articles published between January 1, 2009, and January 20, 2026, was conducted.
evidence level4
citationPyrsopoulos Nikolaos T. (2026)
sourceReducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review