topicInulin Constipation Meta-Analysis
claimIn particular, it may be effective in the management of conditions such as hypertension, diabetes, and liver disease, alongside other potential health benefits, such as its ability to support gastrointestinal health, cardiovascular risk reduction, and metabolic control.
evidence level4
citationSanlier Nevin (2026)
sourceFrom Husks and Seeds to Health: an Inevitable Outcome Rather than a Fluke
topicInulin Constipation Meta-Analysis
claimStudies also emphasize its various metabolic and hepatoprotective effects, including the modulation of bile acid metabolism and the activation of pathways associated with the farnesoid X receptor.
evidence level4
citationSanlier Nevin (2026)
sourceFrom Husks and Seeds to Health: an Inevitable Outcome Rather than a Fluke
topicInulin Constipation Meta-Analysis
claimIn an animal study conducted with rats, psyllium was found to have antioxidant and anti-inflammatory effects [].
evidence level4
citationSanlier Nevin (2026)
sourceFrom Husks and Seeds to Health: an Inevitable Outcome Rather than a Fluke
topicInulin Constipation Meta-Analysis
claimPlantago ovata 1 2 3 4 5 The shells or husks ofseeds, also known as psyllium, ispaghula, or isabgol, are attracting attention in recent years due to their health benefits [,].
evidence level4
citationSanlier Nevin (2026)
sourceFrom Husks and Seeds to Health: an Inevitable Outcome Rather than a Fluke
topicInulin Constipation Meta-Analysis
claimDesigned as a narrative review employing systematic search strategies to ensure comprehensive coverage while accommodating evidence heterogeneity, this study evaluates the efficacy and safety of probiotics, prebiotics, and synbiotics (PP/S) in FC with comorbid depression.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.
topicInulin Constipation Meta-Analysis
claimUsing the terms "probiotic/prebiotic/synbiotic," "functional constipation," and "depression" as subject headings and free-text keywords, we analyzed the available evidence.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.
topicInulin Constipation Meta-Analysis
claimCurrent evidence suggests that, in adults (including some older adults), PP/S are associated with improvements in spontaneous bowel movements and stool form (Bristol Stool Form Scale), alongside reductions in abdominal symptoms.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.
topicInulin Constipation Meta-Analysis
claimFunctional constipation (FC) commonly co-occurs with depression, with the microbiota-gut-brain axis providing a biological basis for this association.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.