topicInositol Pms Randomized Trial
claimSerum total antioxidant capacity, glutathione peroxidase, reduced glutathione, and other biochemical and clinical parameters were assessed preand post-intervention.
evidence level2
citationHatami A (2026)
sourceThe Effect of Vitex Agnus - Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clinical Trial Study.
topicInositol Pms Randomized Trial
claimResults Compared to placebo, Vitex significantly increased total antioxidant capacity (effect size = 13.01), glutathione peroxidase (3.35), reduced glutathione (3.88), total thiol (3.34), and HDL (5.74) (all p Conclusions Vitex agnus-castus improved oxidative stress markers and insulin resistance and favorably modulated clinical manifestations of PCOS.
evidence level2
citationHatami A (2026)
sourceThe Effect of Vitex Agnus - Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clinical Trial Study.
topicInositol Pms Randomized Trial
claimObjective This randomized controlled trial investigated the efficacy of standardized Vitex agnus-castus extract in managing features of PCOS.
evidence level2
citationHatami A (2026)
sourceThe Effect of Vitex Agnus - Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clinical Trial Study.
topicInositol Pms Randomized Trial
claimThe primary aim was to assess changes in oxidative stress markers; secondary outcomes included lipid profile, insulin resistance, and clinical signs such as hirsutism and menstrual frequency.
evidence level2
citationHatami A (2026)
sourceThe Effect of Vitex Agnus - Castus Plant on Some Markers of Oxidative Stress, Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind Controlled Clinical Trial Study.
topicInositol Pms Randomized Trial
claimWhile no prior protocol was registered, no quantitative meta-analysis was performed, and a formal risk-of-bias assessment of individual studies was not conducted.
evidence level3
citationAlsuwaidi Azza (2026)
sourceEndocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications
topicInositol Pms Randomized Trial
claimEligible studies included observational research, randomized controlled trials, and mechanistic investigations examining vitamin D status, supplementation, VDR activity, or associated reproductive outcomes.
evidence level3
citationAlsuwaidi Azza (2026)
sourceEndocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications
topicInositol Pms Randomized Trial
claimThroughout this review, evidence hierarchy was considered when drawing conclusions about therapeutic efficacy.
evidence level3
citationAlsuwaidi Azza (2026)
sourceEndocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications
topicInositol Pms Randomized Trial
claim1 Vitamin D is a fat-soluble steroid hormone that acts more like a hormone than a traditional vitamin, relying on cutaneous synthesis triggered by UVB exposure, subsequent hydroxylation in the liver and kidneys, and transport via vitamin D binding protein (VDBP) to mediate its biological effects.
evidence level3
citationAlsuwaidi Azza (2026)
sourceEndocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications