topicInositol Insulin Sensitivity Meta-Analysis
claimObjectives This umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of the existing body of evidence.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicInositol Insulin Sensitivity Meta-Analysis
claimGRADE assessment of 85 evidence items revealed no high-quality evidence; 18.9% were moderate, 40% low, and 41.1% very low quality.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicInositol Insulin Sensitivity Meta-Analysis
claimPooled analyses demonstrated that inositol significantly improved multiple outcomes compared to placebo/FA: it reduced serum luteinizing hormone (LH: MD -3.43 IU/L, 95% CI [-4.29, -2.56], P P P P P P = 0.03; ovulation rate: RR 2.75, 95% CI [1.71, 4.41], P Conclusion Inositol improves core PCOS manifestations.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicInositol Insulin Sensitivity Meta-Analysis
claimMethods We searched four databases from inception to August 2025 for relevant RCT meta-analyses.
evidence level2
citationDuan M (2026)
sourceEffects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials.
topicInositol Insulin Sensitivity Meta-Analysis
claimIt is often associated with hormonal imbalance, metabolic disturbances, and reproductive complications, which together contribute to an elevated risk of long-term cardiometabolic disorders.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicInositol Insulin Sensitivity Meta-Analysis
claimTo narratively synthesize mechanistic rationale and human clinical evidence on dietary seeds and selected nutraceuticals relevant to PCOS, with emphasis on metabolic and reproductive endpoints of interest to nutrition and obstetrics/gynecology practice.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicInositol Insulin Sensitivity Meta-Analysis
claimProposed "seed cycling" protocols have received attention, yet most clinical data are derived from mixed-seed supplementation studies or low-level evidence, such as case reports, and should be considered hypothesis-generating.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicInositol Insulin Sensitivity Meta-Analysis
claimPolycystic ovary syndrome (PCOS) represents one of the most common endocrine disorders among women of reproductive age.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.