Structured evidence table for Inositol Insomnia Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Inositol Insomnia Meta-Analysis | Major Depressive Disorder (MDD) diagnoses have drastically increased in the United States from 6.5% to 21-30% since 2019, burdening individuals and society alike. | 1 | White AJ (2026) | Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis. |
| Inositol Insomnia Meta-Analysis | We found that subjects with MDD had significantly decreased N-acetylaspartate (NAA; Hedges' g = -0.16, 95% CI -0.299 to -0.030, p = 0.017), and gamma-aminobutyric acid (GABA; Hedges' g = -0.26, 95% CI -0.434 to -0.082, p = 0.004), and increased levels of glutamine (Gln; Hedges' g = 0.21, 95% CI 0.105 to 0.311, p < 0.001) in the ACC. | 1 | White AJ (2026) | Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis. |
| Inositol Insomnia Meta-Analysis | Subgroup analyses suggested significantly increased NAA detected by magnets stronger than 1.5 Tesla only, glutamate (Glu) in the dorsal ACC only and significantly increased myo-inositol (mI) and choline (Cho) in exclusively unmedicated subjects. | 1 | White AJ (2026) | Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis. |
| Inositol Insomnia Meta-Analysis | Despite considerable efforts to understand the pathogenesis of MDD, the heterogeneity of the disorder has made it difficult to delineate its underpinnings, highlighting the need for biomarker identification. | 1 | White AJ (2026) | Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis. |
| Inositol Insomnia Meta-Analysis | Evidence review A systematic literature review and meta-analysis were conducted using PubMed/MEDLINE, Embase, and Web of Science (2015-2024), following PRISMA guidelines. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Inositol Insomnia Meta-Analysis | Conclusion Available evidence suggests that melatonin-containing supplements may be associated with improved BMD in menopausal women, but the independent effect of melatonin and an optimal dose remain unclear due to heterogeneity in interventions and the prevalent use of combination therapies. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Inositol Insomnia Meta-Analysis | For other outcomes (sleep, menopausal symptoms, mood, sexual function, BMI, and insulin), the evidence is currently inconclusive. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Inositol Insomnia Meta-Analysis | Objective This study evaluated the impact of melatonin supplementation on bone mineral density (BMD), sleep quality, menopausal symptoms, mood, sexual function, serum insulin levels, and body mass index in menopausal women. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
Source documents