topicHyaluronic Acid Skin Health Randomized Trial
claimBackground/objectives The skin is the largest organ of the human body and undergoes age-related changes, such as reduced hydration, loss of elasticity, and wrinkle formation, which can affect appearance and quality of life.
evidence level2
citationSeto Y (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
topicHyaluronic Acid Skin Health Randomized Trial
claimIn addition, wrinkle grades showed that wrinkles improved significantly in the piceatannol group compared to in the placebo.
evidence level2
citationSeto Y (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
topicHyaluronic Acid Skin Health Randomized Trial
claimConclusion Intake of piceatannol could serve as an effective dietary intervention for improving skin hydration and wrinkles.
evidence level2
citationSeto Y (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
topicHyaluronic Acid Skin Health Randomized Trial
claimPiceatannol has antioxidant and anti-inflammatory properties and has attracted attention as a functional ingredient for maintaining skin health.
evidence level2
citationSeto Y (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
topicHyaluronic Acid Skin Health Randomized Trial
claimNutraceuticals represent promising strategies for preventing, delaying and addressing premature aging of the skin, especially as women advance in years (particularly after 30 years of age, when estrogen levels begin to decline, and remarkably after menopause when estrogen production ceases from the ovaries).
evidence level4
citationArbex P (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels -A Narrative Review.
topicHyaluronic Acid Skin Health Randomized Trial
claimThis review is part of a larger project, and we present this companion review, which provides a detailed examination of the literature beyond polyphenols and/or phytoestrogens for estrogen-deficient skin.
evidence level4
citationArbex P (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels -A Narrative Review.