Structured evidence table for Hmb Muscle Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Hmb Muscle Meta-Analysis | The Cochrane ROB2 tool and GRADE framework were used to assess the risk of bias and evidence certainty. | 1 | Xie C (2026) | Combined resistance training and amino acid-based supplementation for sarcopenia in older adults: a systematic review and meta-analysis. |
| Hmb Muscle Meta-Analysis | Conclusion Resistance training combined with amino acid supplementation may improve muscle strength and physical function in older adults with sarcopenia, although effects on muscle mass remain limited. | 1 | Xie C (2026) | Combined resistance training and amino acid-based supplementation for sarcopenia in older adults: a systematic review and meta-analysis. |
| Hmb Muscle Meta-Analysis | Background and objective Resistance training is the cornerstone of sarcopenia management. | 1 | Xie C (2026) | Combined resistance training and amino acid-based supplementation for sarcopenia in older adults: a systematic review and meta-analysis. |
| Hmb Muscle Meta-Analysis | However, whether combining it with amino acid-based supplementation, including essential amino acids, branched-chain amino acids, leucine, and derivatives such as HMB, provides additional benefits remains unclear. | 1 | Xie C (2026) | Combined resistance training and amino acid-based supplementation for sarcopenia in older adults: a systematic review and meta-analysis. |
| Hmb Muscle Meta-Analysis | Background Elevated branched-chain amino acids (BCAAs; leucine, valine, isoleucine) are linked to type 2 diabetes (T2D) risk, characterised by defective insulin secretion in pancreatic β-cell and peripheral insulin resistance. | 4 | Zhou X (2026) | Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. |
| Hmb Muscle Meta-Analysis | Methods Using publicly available datasets from the European population, we conducted a meta-analysis of genome-wide association studies (GWAS), followed by multi-trait analysis of GWAS (MTAG), to identify genetic loci associated with BCAAs and their catabolites. | 4 | Zhou X (2026) | Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. |
| Hmb Muscle Meta-Analysis | Genetically elevated valine had a significant association with increased insulin fold change during oral glucose challenge test (OGTT) (β [95% CI] = 0.135 [0.045, 0.225]), False discovery rate adjusted p-value (p FDR = 0.022), and suggestive association with fasting glucose level (β [95% CI] = 0.031 [0.004, 0.058], inverse-variance weighted p-value [p IVW ] = 0.025). | 4 | Zhou X (2026) | Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. |
| Hmb Muscle Meta-Analysis | Causative interaction between BCAA metabolism and these two diabetic pathogenesis remains unclear. | 4 | Zhou X (2026) | Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. |
Source documents