topicGreen-Lipped Mussel Joint Function Randomized Trial
claimBackground Knee osteoarthritis (OA) is a prevalent degenerative joint disease associated with pain, functional limitation, and reduced quality of life.
evidence level2
citationKim HT (2026)
sourceEfficacy and safety of green-lipped mussel powder supplementation in adults with knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
topicGreen-Lipped Mussel Joint Function Randomized Trial
claimSignificant between-group differences were also observed for WOMAC pain (p = 0.026), WOMAC physical function (p = 0.027), and VAS pain (between-group difference - 19.93 mm; 95% CI - 25.31 to - 14.55; p Conclusions Twelve-week supplementation with GLMP was associated with improvements in pain and physical function in adults with mild-to-moderate knee OA.
evidence level2
citationKim HT (2026)
sourceEfficacy and safety of green-lipped mussel powder supplementation in adults with knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
topicGreen-Lipped Mussel Joint Function Randomized Trial
claimAlthough nonsteroidal anti-inflammatory drugs are widely prescribed, long-term use is limited by safety concerns.
evidence level2
citationKim HT (2026)
sourceEfficacy and safety of green-lipped mussel powder supplementation in adults with knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
topicGreen-Lipped Mussel Joint Function Randomized Trial
claimFucoidan, an extract from seaweed Undaria pinnatifida , has been found to have beneficial effects on joint pain and insulin resistance.
evidence level2
citationTay A (2022)
sourceCombining mussel with fucoidan as a supplement for joint pain and prediabetes: Study protocol for a randomized, double-blinded, placebo-controlled trial.
topicGreen-Lipped Mussel Joint Function Randomized Trial
claimIntroduction Pharmaceutical drugs are beneficial to inflammatory conditions but with side effects, which led to the search for alternative therapies.
evidence level2
citationTay A (2022)
sourceCombining mussel with fucoidan as a supplement for joint pain and prediabetes: Study protocol for a randomized, double-blinded, placebo-controlled trial.
topicGreen-Lipped Mussel Joint Function Randomized Trial
claimPerna canaliculus , the New Zealand green-lipped mussel, have shown promise in placebo-controlled trials for inflammatory conditions.
evidence level2
citationTay A (2022)
sourceCombining mussel with fucoidan as a supplement for joint pain and prediabetes: Study protocol for a randomized, double-blinded, placebo-controlled trial.