topicGrapeseed Skin Hydration Meta-Analysis
claimA meta-analysis of TEWL results found that TEWL values were not significantly different in subjects treated with ceramide-containing moisturisers (mean difference: -3.56, 95% CI [-8.63, 1.52], P = 0.17) with high heterogeneity (I 2 = 92%) compared to other treatments.
evidence level1
citationNugroho WT (2023)
sourceThe Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis.
topicGrapeseed Skin Hydration Meta-Analysis
claimAtopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin condition that recurs frequently and has diverse clinical features.
evidence level1
citationNugroho WT (2023)
sourceThe Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis.
topicGrapeseed Skin Hydration Meta-Analysis
claimOne of the causes of stratum corneum (SC) structural integrity disruption is the decreased production of ceramide, an important lipid component in SC.
evidence level1
citationNugroho WT (2023)
sourceThe Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis: A Systematic Literature Review and Meta-Analysis.
topicGrapeseed Skin Hydration Meta-Analysis
claim1 2 3 4 3 5 Aging is an unavoidable phase of life, which is a multifactorial transition process, like biological changes, that is characterized by the progressive decline of physiological activity and the increased vulnerability to age‐related disorders like osteoporosis and Alzheimer's.
evidence level3
citationSuvedi Divyesh (2025)
sourceAging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential
topicGrapeseed Skin Hydration Meta-Analysis
claim6 7 In ancient times, anti‐aging treatments generally focused on the skin, which is the most outward organ of the body and showed the most affected result of aging.
evidence level3
citationSuvedi Divyesh (2025)
sourceAging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential
topicGrapeseed Skin Hydration Meta-Analysis
claimWhile effective in providing immediate cosmetic results, they also have very severe limitations, such as high price, potential side effects (e.g., skin redness, allergic contact dermatitis, post‐inflammatory hyperpigmentation), and scarce long‐term safety evidence.
evidence level3
citationSuvedi Divyesh (2025)
sourceAging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential
topicGrapeseed Skin Hydration Meta-Analysis
claimIt first begins at the cellular level and continues throughout the lifespan, ultimately turning into death [].
evidence level3
citationSuvedi Divyesh (2025)
sourceAging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential