topicGrape Polyphenols Cognitive Performance Randomized Trial
claimChronic low-grade and immune-mediated inflammation underlies the pathophysiology of metabolic and systemic tissue dysfunction associated with cardiometabolic disease development and accelerated aging, whereas therapeutic and preventative strategies to reduce inflammation and promote immune function yield beneficial health outcomes.
evidence level3
citationGaddam I (2026)
sourceEffects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimEvidence from cell and animal studies demonstrates that consumption of grapes, grape-based extracts and preparations, and grape-derived bioactive compounds exert beneficial anti-inflammatory and immunomodulatory effects, which are associated with improvements in metabolic profiles.
evidence level3
citationGaddam I (2026)
sourceEffects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimHowever, results from human intervention trials investigating grape effects on inflammatory and immune markers are more limited and report varied effects on improvements in clinical and experimental biomarkers indicative of cardiometabolic disease risk and healthy aging, such as serum lipids, blood pressure, insulin resistance, oxidative stress, gut dysbiosis, and cognitive function.
evidence level3
citationGaddam I (2026)
sourceEffects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimCardiometabolic disease and age-related health complications are significant clinical and public health concerns that impact an individual's overall quality of life and longevity.
evidence level3
citationGaddam I (2026)
sourceEffects of Grape and Grape-Derived Bioactives on Inflammation and Immune-Driven Mechanisms Within the Context of Cardiometabolic Health and Aging: A Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimVascular aging is a key determinant of cardiovascular risk and is characterized by endothelial dysfunction, oxidative stress, inflammation, arterial stiffness, and alterations of the endothelial glycocalyx.
evidence level4
citationKatsanaki E (2026)
sourceEffects of Nutritional Supplements on Vascular Function: A Narrative Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimThe objective of this narrative review is to summarize and critically evaluate the current evidence regarding the effects of selected nutritional supplements on endothelial function and vascular health, with emphasis on their proposed mechanisms of action, available preclinical and clinical evidence, and current limitations.
evidence level4
citationKatsanaki E (2026)
sourceEffects of Nutritional Supplements on Vascular Function: A Narrative Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimOverall, current evidence suggests that several nutritional supplements may improve surrogate markers of vascular function; however, evidence demonstrating reductions in major cardiovascular events or cardiovascular mortality remains limited.
evidence level4
citationKatsanaki E (2026)
sourceEffects of Nutritional Supplements on Vascular Function: A Narrative Review.
topicGrape Polyphenols Cognitive Performance Randomized Trial
claimIn recent years, increasing scientific interest has focused on whether selected nutritional supplements can modulate these mechanisms.
evidence level4
citationKatsanaki E (2026)
sourceEffects of Nutritional Supplements on Vascular Function: A Narrative Review.