evidence table

Glycine Muscle Soreness Randomized Trial Evidence Table

Structured evidence table for Glycine Muscle Soreness Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Glycine Muscle Soreness Randomized TrialResults : During the supplementation, CrM improved sleep quality compared to PL, as measured with the SSQ scale ( d = 0.81, p = 0.009), and was associated with an earlier in-bed time (r = 0.60; p = 0.026).2Ben Maaoui K (2025)Effects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Glycine Muscle Soreness Randomized TrialAfter the supplementation phase, CrM resulted in significantly lower muscle soreness scores, as measured by the Hooper questionnaire ( d = -0.59; p = 0.046), improved cognitive performance on the DCT ( d = 0.77; p = 0.013), and enhanced TD (r = 0.88; p p p > 0.05).2Ben Maaoui K (2025)Effects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Glycine Muscle Soreness Randomized TrialConclusions : A 7-day CrM loading protocol improved subjective sleep quality during the supplementation phase, enhanced cognitive performance, and increased physical output during high-intensity intermittent exercise.2Ben Maaoui K (2025)Effects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Glycine Muscle Soreness Randomized TrialBackground/Objectives: Creatine monohydrate (CrM) supplementation is well-established for enhancing physical performance and accelerating recovery in several sporting contexts.2Ben Maaoui K (2025)Effects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Glycine Muscle Soreness Randomized Trial1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Glycine Muscle Soreness Randomized Trial1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Glycine Muscle Soreness Randomized TrialLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Glycine Muscle Soreness Randomized TrialIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicGlycine Muscle Soreness Randomized Trial
claimResults : During the supplementation, CrM improved sleep quality compared to PL, as measured with the SSQ scale ( d = 0.81, p = 0.009), and was associated with an earlier in-bed time (r = 0.60; p = 0.026).
evidence level2
citationBen Maaoui K (2025)
sourceEffects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
topicGlycine Muscle Soreness Randomized Trial
claimAfter the supplementation phase, CrM resulted in significantly lower muscle soreness scores, as measured by the Hooper questionnaire ( d = -0.59; p = 0.046), improved cognitive performance on the DCT ( d = 0.77; p = 0.013), and enhanced TD (r = 0.88; p p p > 0.05).
evidence level2
citationBen Maaoui K (2025)
sourceEffects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
topicGlycine Muscle Soreness Randomized Trial
claimConclusions : A 7-day CrM loading protocol improved subjective sleep quality during the supplementation phase, enhanced cognitive performance, and increased physical output during high-intensity intermittent exercise.
evidence level2
citationBen Maaoui K (2025)
sourceEffects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
topicGlycine Muscle Soreness Randomized Trial
claimBackground/Objectives: Creatine monohydrate (CrM) supplementation is well-established for enhancing physical performance and accelerating recovery in several sporting contexts.
evidence level2
citationBen Maaoui K (2025)
sourceEffects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
topicGlycine Muscle Soreness Randomized Trial
claim1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicGlycine Muscle Soreness Randomized Trial
claim1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicGlycine Muscle Soreness Randomized Trial
claimLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicGlycine Muscle Soreness Randomized Trial
claimIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults

Learn next

Related evidence and supplement guides

SupplementGlycineNon-essential amino acid that cools core body temperature and deepens slow-wave sleep — remarkab...GuideGlycine Muscle Soreness Randomized Trial: What the Evidence SaysGlycine Muscle Soreness Randomized Trial has 2 source documents in the current Migaku evidence d...GuideBee Pollen Muscle Soreness Randomized Trial: What the Evidence SaysBee Pollen Muscle Soreness Randomized Trial has 2 source documents in the current Migaku evidenc...GuideGlycine Muscle Recovery Randomized Trial: What the Evidence SaysGlycine Muscle Recovery Randomized Trial has 1 source documents in the current Migaku evidence d...GuideCitrulline Muscle Soreness Randomized Trial: What the Evidence SaysCitrulline Muscle Soreness Randomized Trial has 2 source documents in the current Migaku evidenc...AnswerDoes Bee Pollen Muscle Soreness Randomized Trial work?Bee Pollen Muscle Soreness Randomized Trial has evidence relevant to strength of evidence and wh...AnswerIs Bee Pollen Muscle Soreness Randomized Trial safe?Bee Pollen Muscle Soreness Randomized Trial has evidence relevant to safety, limits, and clinici...AnswerWhat does the evidence say about Bee Pollen Muscle Soreness Randomized Trial?Bee Pollen Muscle Soreness Randomized Trial has evidence relevant to benefits, uncertainty, and...

Source documents

  1. Effects of Creatine Monohydrate Loading on Sleep Metrics, Physical Performance, Cognitive Function, and Recovery in Physically Active Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
  2. Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults