topicGlucosamine Joint Stiffness Randomized Trial
claimIt causes chronic pain, reduced mobility, and disability, affecting 607 million individuals worldwide, with nearly 46.6 million new cases annually [].
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicGlucosamine Joint Stiffness Randomized Trial
claim11 12 13 14 15 11 15 HLA-DRB1 HLA-DQB1 Genetic polymorphisms in sterol regulatory element-binding protein 2 (rs2228314) [], interleukin-6 (rs1800795) [], and resistin (RETN) [] in Indian and Pakistani cohorts and growth differentiation factor 5 (rs143383) [],, andin Thai populations [] are linked to OA risk.
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicGlucosamine Joint Stiffness Randomized Trial
claimNeed for expert opinion Despite growing clinical and mechanistic evidence for collagen supplementation in OA, several gaps and challenges remain in translating this knowledge into clinical practice, especially in the Indian subcontinent and Southeast Asia.
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicGlucosamine Joint Stiffness Randomized Trial
claim1 2 3 4 6 7 8 9 10 1 Osteoarthritis (OA) is the most prevalent degenerative joint disease globally and the second most common rheumatologic condition [].
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicGlucosamine Joint Stiffness Randomized Trial
claimlonga extract produced a significant reduction in pain and clinical signs associated with OA.
evidence level4
citationTripathi SD (2026)
sourceProtective effects of turmerosaccharides rich extract of <i>Curcuma longa</i> L. in osteoarthritic dogs.
topicGlucosamine Joint Stiffness Randomized Trial
claimIntroduction Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage deterioration, leading to chronic pain and impaired immobility particularly in older dogs.
evidence level4
citationTripathi SD (2026)
sourceProtective effects of turmerosaccharides rich extract of <i>Curcuma longa</i> L. in osteoarthritic dogs.
topicGlucosamine Joint Stiffness Randomized Trial
claimAim This study investigated the protective effects of a turmerosaccharides-rich extract of Curcuma longa L.
evidence level4
citationTripathi SD (2026)
sourceProtective effects of turmerosaccharides rich extract of <i>Curcuma longa</i> L. in osteoarthritic dogs.