joint health

Glucosamine Joint Function Meta-Analysis Evidence Table

Structured evidence table for Glucosamine Joint Function Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Glucosamine Joint Function Meta-AnalysisThis umbrella review synthesized evidence from published systematic reviews and meta-analyses on the effectiveness and safety of glucosamine in knee OA.3Li Y (2026)Glucosamine for knee osteoarthritis: an umbrella review.
Glucosamine Joint Function Meta-AnalysisGlucosamine was associated with significant slowing of JSN progression (SMD - 0.32, p = 0.01), though this signal derived mainly from long-duration sulfate trials.3Li Y (2026)Glucosamine for knee osteoarthritis: an umbrella review.
Glucosamine Joint Function Meta-AnalysisConclusion Glucosamine demonstrated at most minimal-to-modest efficacy for knee OA, yielding a small pain reduction and possible slowing of radiographic progression but no clear functional benefit, with effects at or below the threshold of clinical importance.3Li Y (2026)Glucosamine for knee osteoarthritis: an umbrella review.
Glucosamine Joint Function Meta-AnalysisBackground Knee osteoarthritis (OA) is a common cause of pain and disability without a cure.3Li Y (2026)Glucosamine for knee osteoarthritis: an umbrella review.
Glucosamine Joint Function Meta-AnalysisBackground Osteoporosis (OP) associated with knee osteoarthritis (KOA) is common in older men and postmenopausal women, and it is important to find reliable and effective treatments for this disease to improve joint function and bone metabolism in this population.4Yang JJ (2022)Clinical Efficacy of Glucosamine plus Sodium Hyaluronate for Osteoporosis Complicated by Knee Osteoarthritis and Its Influence on Joint Function and Bone Metabolic Markers.
Glucosamine Joint Function Meta-AnalysisObjective To clarify the clinical efficacy of glucosamine (GlcN) plus sodium hyaluronate (SH) for OP complicated by KOA (OP + KOA) and its influence on joint function and bone metabolic markers (BMMs).4Yang JJ (2022)Clinical Efficacy of Glucosamine plus Sodium Hyaluronate for Osteoporosis Complicated by Knee Osteoarthritis and Its Influence on Joint Function and Bone Metabolic Markers.
topicGlucosamine Joint Function Meta-Analysis
claimThis umbrella review synthesized evidence from published systematic reviews and meta-analyses on the effectiveness and safety of glucosamine in knee OA.
evidence level3
citationLi Y (2026)
sourceGlucosamine for knee osteoarthritis: an umbrella review.
topicGlucosamine Joint Function Meta-Analysis
claimGlucosamine was associated with significant slowing of JSN progression (SMD - 0.32, p = 0.01), though this signal derived mainly from long-duration sulfate trials.
evidence level3
citationLi Y (2026)
sourceGlucosamine for knee osteoarthritis: an umbrella review.
topicGlucosamine Joint Function Meta-Analysis
claimConclusion Glucosamine demonstrated at most minimal-to-modest efficacy for knee OA, yielding a small pain reduction and possible slowing of radiographic progression but no clear functional benefit, with effects at or below the threshold of clinical importance.
evidence level3
citationLi Y (2026)
sourceGlucosamine for knee osteoarthritis: an umbrella review.
topicGlucosamine Joint Function Meta-Analysis
claimBackground Knee osteoarthritis (OA) is a common cause of pain and disability without a cure.
evidence level3
citationLi Y (2026)
sourceGlucosamine for knee osteoarthritis: an umbrella review.
topicGlucosamine Joint Function Meta-Analysis
claimBackground Osteoporosis (OP) associated with knee osteoarthritis (KOA) is common in older men and postmenopausal women, and it is important to find reliable and effective treatments for this disease to improve joint function and bone metabolism in this population.
evidence level4
citationYang JJ (2022)
sourceClinical Efficacy of Glucosamine plus Sodium Hyaluronate for Osteoporosis Complicated by Knee Osteoarthritis and Its Influence on Joint Function and Bone Metabolic Markers.
topicGlucosamine Joint Function Meta-Analysis
claimObjective To clarify the clinical efficacy of glucosamine (GlcN) plus sodium hyaluronate (SH) for OP complicated by KOA (OP + KOA) and its influence on joint function and bone metabolic markers (BMMs).
evidence level4
citationYang JJ (2022)
sourceClinical Efficacy of Glucosamine plus Sodium Hyaluronate for Osteoporosis Complicated by Knee Osteoarthritis and Its Influence on Joint Function and Bone Metabolic Markers.

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Source documents

  1. Glucosamine for knee osteoarthritis: an umbrella review.
  2. Clinical Efficacy of Glucosamine plus Sodium Hyaluronate for Osteoporosis Complicated by Knee Osteoarthritis and Its Influence on Joint Function and Bone Metabolic Markers.