topicGlucosamine Joint Comfort Randomized Trial
claimBackground Osteoarthritis is a common joint disease, especially among individuals aged 50 and older, leading to symptoms such as pain, stiffness, and functional limitations, particularly in weight-bearing joints like the knees.
evidence level2
citationČeh T (2026)
sourceComplementary effect of a combined exercise and dietary supplement intervention in individuals with knee osteoarthritis: study protocol for a randomized, double-blind, placebo-controlled trial.
topicGlucosamine Joint Comfort Randomized Trial
claimKnee osteoarthritis (KOA) is increasingly prevalent, making effective treatment strategies critical.
evidence level2
citationČeh T (2026)
sourceComplementary effect of a combined exercise and dietary supplement intervention in individuals with knee osteoarthritis: study protocol for a randomized, double-blind, placebo-controlled trial.
topicGlucosamine Joint Comfort Randomized Trial
claimConclusion CEFFE is an alternative biosafety method for the biological treatment of knee OA, with symptom improvement and BML reduction, and has promising potential for clinical application.
evidence level4
citationXie K (2026)
sourceSafety and Efficacy of Intra-articular Cell-Free Fat Extract Injection in Patients With Symptomatic Knee Osteoarthritis.
topicGlucosamine Joint Comfort Randomized Trial
claimBackground Cell-free fat extract (CEFFE) has shown promising therapeutic effects on osteoarthritis (OA) in preclinical studies, but its clinical role remains unclear.
evidence level4
citationXie K (2026)
sourceSafety and Efficacy of Intra-articular Cell-Free Fat Extract Injection in Patients With Symptomatic Knee Osteoarthritis.
topicGlucosamine Joint Comfort Randomized Trial
claimPurpose To evaluate the safety and efficacy of intra-articular autologous CEFFE injections for symptomatic early- and mid-stage knee OA.
evidence level4
citationXie K (2026)
sourceSafety and Efficacy of Intra-articular Cell-Free Fat Extract Injection in Patients With Symptomatic Knee Osteoarthritis.