Structured evidence table for Folate Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Folate Cognition Meta-Analysis | Concurrently, the number of individuals affected by dementia is anticipated to nearly triple by 2050, with associated treatment costs projected to reach US$2.8 trillion by 2030 []. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Folate Cognition Meta-Analysis | In addition, omega-3 fatty acids support synaptic plasticity and exert anti-inflammatory effects; however, evidence is mixed, as randomized trials in healthy older adults show limited benefits [,], while several analyses report modest improvements in aged or MCI patients [,]. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Folate Cognition Meta-Analysis | Observational studies and recent trials involving antioxidant nutrients, such as pomegranate juice and resveratrol, alongside polyphenols, suggest potential protection for specific cognitive domains (e.g., memory) and reduced dementia risk, although effects are heterogeneous and causality remains unconfirmed [,]. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Folate Cognition Meta-Analysis | 1 2 3 4 5 6 7 8 9 10 The World Health Organization (WHO) projects that by 2050, the global population aged 60 and above will reach 2.1 billion, highlighting the inevitability of global aging []. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Folate Cognition Meta-Analysis | Objective This global systematic review and meta-analysis aims to address the gap in comprehensive evidence on the prevalence of adolescent folate deficiency. | 1 | Aweke MN (2026) | Global folate deficiency among adolescent girls: A systematic review and meta-analysis. |
| Folate Cognition Meta-Analysis | Study quality was assessed using the Newcastle-Ottawa Scale, and evidence certainty was evaluated using GRADE. | 1 | Aweke MN (2026) | Global folate deficiency among adolescent girls: A systematic review and meta-analysis. |
| Folate Cognition Meta-Analysis | The pooled global prevalence of folate deficiency among adolescent girls was 26.9%(95% CI: 20.5-33.2), with substantial heterogeneity observed between studies (I² = 99.99%, p Conclusion These findings revealed folate deficiency as a substantial global public health concern among adolescent girls with a disproportionately high burden in low-resource settings. | 1 | Aweke MN (2026) | Global folate deficiency among adolescent girls: A systematic review and meta-analysis. |
| Folate Cognition Meta-Analysis | Introduction Adolescents have higher nutrient requirements than adults, as this stage accounts for approximately 40% of total adult weight gain, 45% of skeletal mass and about 15% of adult height. | 1 | Aweke MN (2026) | Global folate deficiency among adolescent girls: A systematic review and meta-analysis. |
Source documents