topicFolate Blood Pressure Meta-Analysis
claimEpidemiological evidence highlights both the high prevalence and serious consequences of these disorders.
evidence level3
citationZhang Tingyin (2026)
sourceMultigene Screening of B-Vitamin Metabolism Pathways in Hypertensive Disorders of Pregnancy: Toward Precision Prenatal Care
topicFolate Blood Pressure Meta-Analysis
claimFor instance, a large national cohort study in China involving more than two million pregnant women reported that ambient environmental factors, such as temperature fluctuations, can influence the incidence of preeclampsia and gestational hypertension, underscoring the multifactorial nature of HDP.The global burden of HDP is also reflected in its associated maternal and perinatal morbidity and mortality.
evidence level3
citationZhang Tingyin (2026)
sourceMultigene Screening of B-Vitamin Metabolism Pathways in Hypertensive Disorders of Pregnancy: Toward Precision Prenatal Care
topicFolate Blood Pressure Meta-Analysis
claimAffected women have increased risks of cardiovascular and cerebrovascular diseases, cognitive decline, and other neurological disorders later in life.Collectively, these findings highlight the critical need for early diagnosis, careful risk stratification, and effective management strategies to reduce both immediate and long-term adverse outcomes associated with HDP.
evidence level3
citationZhang Tingyin (2026)
sourceMultigene Screening of B-Vitamin Metabolism Pathways in Hypertensive Disorders of Pregnancy: Toward Precision Prenatal Care
topicFolate Blood Pressure Meta-Analysis
claim1 2 3 4 5–7 HDP remain a major clinical challenge worldwide, posing substantial risks to both maternal and fetal well-being.
evidence level3
citationZhang Tingyin (2026)
sourceMultigene Screening of B-Vitamin Metabolism Pathways in Hypertensive Disorders of Pregnancy: Toward Precision Prenatal Care
topicFolate Blood Pressure Meta-Analysis
claim3 3 4 4 5 7 8 11 Metabolic diseases, an array of disorders including type 2 diabetes (T2D) and obesity, and risk factors such as hypertension and hyperlipidaemia have also been increasing globally [].
evidence level3
citationYoo Samantha (2026)
sourceFolate and global health review series, part 3: syntheses on cardiovascular, cerebrovascular, and metabolic diseases
topicFolate Blood Pressure Meta-Analysis
claimMetabolic disorders often occur concurrently and are risk factors associated with CVDs [–], with associations between metabolic syndrome and cardiovascular morbidity and mortality being well-documented [–].
evidence level3
citationYoo Samantha (2026)
sourceFolate and global health review series, part 3: syntheses on cardiovascular, cerebrovascular, and metabolic diseases
topicFolate Blood Pressure Meta-Analysis
claimMore specifically, the blood concentration of homocysteine is a well-established risk factor for vascular damage and atherosclerosis, and can be lowered with higher intakes of folate [–].
evidence level3
citationYoo Samantha (2026)
sourceFolate and global health review series, part 3: syntheses on cardiovascular, cerebrovascular, and metabolic diseases
topicFolate Blood Pressure Meta-Analysis
claim1 2 Cardiovascular diseases (CVDs) encompass multiple subcategories of conditions, including coronary artery disease (CAD), heart failure, cerebrovascular diseases, cardiomyopathy, and peripheral artery disease.
evidence level3
citationYoo Samantha (2026)
sourceFolate and global health review series, part 3: syntheses on cardiovascular, cerebrovascular, and metabolic diseases