topicFlaxseed Cardiometabolic Meta-Analysis
claimUnhealthy aging is a growing global concern, characterized by the accelerated decline in physiological and metabolic functions, leading to increased susceptibility to age-related diseases.
evidence level3
citationKunutsor Setor K. (2025)
sourceDietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
topicFlaxseed Cardiometabolic Meta-Analysis
claimAmong these are cardiometabolic diseases, including hypertension, metabolic syndrome (MetS), metabolic dysfunction-associated steatotic liver disease (MASLD), type 2 diabetes (T2D), chronic kidney disease (CKD), and cardiovascular diseases (CVDs), which collectively represent a significant public health burden.
evidence level3
citationKunutsor Setor K. (2025)
sourceDietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
topicFlaxseed Cardiometabolic Meta-Analysis
claimThis condition, characterized by fat accumulation in the liver independent of alcohol consumption, often coexists with obesity, MetS, and T2D, significantly increasing the risk of liver cirrhosis and CVD [].
evidence level3
citationKunutsor Setor K. (2025)
sourceDietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
topicFlaxseed Cardiometabolic Meta-Analysis
claimResults: Compared with the HFD group, curcumin-flaxseed oil supplementation significantly reduced serum TG, TC, and LDL-C levels, while HDL-C remained unchanged.
evidence level4
citationWei PH (2026)
sourceCurcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics.
topicFlaxseed Cardiometabolic Meta-Analysis
claimHepatic TG and TC accumulation also decreased significantly, accompanied by increased fecal TG and TC excretion, with a more pronounced effect in the high-dose group.
evidence level4
citationWei PH (2026)
sourceCurcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics.
topicFlaxseed Cardiometabolic Meta-Analysis
claimHepatic SREBP-1 and ACC mRNA expression increased in the low-dose group, whereas FAS expression remained unchanged.
evidence level4
citationWei PH (2026)
sourceCurcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics.
topicFlaxseed Cardiometabolic Meta-Analysis
claimBackground/Objectives: Dyslipidemia and hepatic lipid buildup are key features of cardiometabolic disorders caused by high-fat, high-cholesterol diets.
evidence level4
citationWei PH (2026)
sourceCurcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics.