metabolic health

Fenugreek Cardiometabolic Randomized Trial Evidence Table

Structured evidence table for Fenugreek Cardiometabolic Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Fenugreek Cardiometabolic Randomized TrialIt is often associated with hormonal imbalance, metabolic disturbances, and reproductive complications, which together contribute to an elevated risk of long-term cardiometabolic disorders.4Singnale P (2026)Role of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
Fenugreek Cardiometabolic Randomized TrialTo narratively synthesize mechanistic rationale and human clinical evidence on dietary seeds and selected nutraceuticals relevant to PCOS, with emphasis on metabolic and reproductive endpoints of interest to nutrition and obstetrics/gynecology practice.4Singnale P (2026)Role of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
Fenugreek Cardiometabolic Randomized TrialProposed "seed cycling" protocols have received attention, yet most clinical data are derived from mixed-seed supplementation studies or low-level evidence, such as case reports, and should be considered hypothesis-generating.4Singnale P (2026)Role of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
Fenugreek Cardiometabolic Randomized TrialPolycystic ovary syndrome (PCOS) represents one of the most common endocrine disorders among women of reproductive age.4Singnale P (2026)Role of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
Fenugreek Cardiometabolic Randomized TrialMacrovascular complications, such as coronary heart disease, peripheral vascular disease, and cerebrovascular disease are the leading cause of morbidity and mortality in the United States.In India patients with T2D exhibited a two-fold risk of coronary artery disease-related deaths compared with white, T2D Europeans.4Rao Amit S. (2020)Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
Fenugreek Cardiometabolic Randomized TrialBased on the reported efficacy of these two spices, we hypothesized that the fortified chapatis would normalize glycemic variables, as well as variables associated with hepatic and cardiovascular disease risk.4Rao Amit S. (2020)Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
Fenugreek Cardiometabolic Randomized TrialOne-half of theseed powder (2.5% of the formulated Atta flour) was a defatted seed powder produced by supercritical carbon dioxide extraction ().As a result of flour supplementation, the fat content increased by 49%, representing 66% and 48% increases in monounsaturated fatty acids and polyunsaturated fatty acids, respectively.4Rao Amit S. (2020)Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
Fenugreek Cardiometabolic Randomized Trial1 i 2 2 ii 3 It has been estimated that in 2019, ∼ 463 million people globally were diabetic (∼90% type 2 diabetes mellitus [DM]), with China (25.1%), India (16.6%), and the United States (6.69%) representing nearly 50% of that total.4Rao Amit S. (2020)Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
topicFenugreek Cardiometabolic Randomized Trial
claimIt is often associated with hormonal imbalance, metabolic disturbances, and reproductive complications, which together contribute to an elevated risk of long-term cardiometabolic disorders.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicFenugreek Cardiometabolic Randomized Trial
claimTo narratively synthesize mechanistic rationale and human clinical evidence on dietary seeds and selected nutraceuticals relevant to PCOS, with emphasis on metabolic and reproductive endpoints of interest to nutrition and obstetrics/gynecology practice.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicFenugreek Cardiometabolic Randomized Trial
claimProposed "seed cycling" protocols have received attention, yet most clinical data are derived from mixed-seed supplementation studies or low-level evidence, such as case reports, and should be considered hypothesis-generating.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicFenugreek Cardiometabolic Randomized Trial
claimPolycystic ovary syndrome (PCOS) represents one of the most common endocrine disorders among women of reproductive age.
evidence level4
citationSingnale P (2026)
sourceRole of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
topicFenugreek Cardiometabolic Randomized Trial
claimMacrovascular complications, such as coronary heart disease, peripheral vascular disease, and cerebrovascular disease are the leading cause of morbidity and mortality in the United States.In India patients with T2D exhibited a two-fold risk of coronary artery disease-related deaths compared with white, T2D Europeans.
evidence level4
citationRao Amit S. (2020)
sourceNigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
topicFenugreek Cardiometabolic Randomized Trial
claimBased on the reported efficacy of these two spices, we hypothesized that the fortified chapatis would normalize glycemic variables, as well as variables associated with hepatic and cardiovascular disease risk.
evidence level4
citationRao Amit S. (2020)
sourceNigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
topicFenugreek Cardiometabolic Randomized Trial
claimOne-half of theseed powder (2.5% of the formulated Atta flour) was a defatted seed powder produced by supercritical carbon dioxide extraction ().As a result of flour supplementation, the fat content increased by 49%, representing 66% and 48% increases in monounsaturated fatty acids and polyunsaturated fatty acids, respectively.
evidence level4
citationRao Amit S. (2020)
sourceNigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
topicFenugreek Cardiometabolic Randomized Trial
claim1 i 2 2 ii 3 It has been estimated that in 2019, ∼ 463 million people globally were diabetic (∼90% type 2 diabetes mellitus [DM]), with China (25.1%), India (16.6%), and the United States (6.69%) representing nearly 50% of that total.
evidence level4
citationRao Amit S. (2020)
sourceNigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study

Learn next

Related evidence and supplement guides

GuideLion's Mane Mushroom: What the Evidence Actually Shows for Brain HealthLegacy library material — check the original sources.GuideNMN and NR: What the Nicotinamide Adenine Dinucleotide Supplements Actually PromiseLegacy library material — check the original sources.GuideCoQ10 (Ubiquinol vs Ubiquinone): Who Benefits and What the Evidence ShowsLegacy library material — check the original sources.GuideCollagen Supplements: What They Can and Cannot Do for Skin and JointsLegacy library material — check the original sources.AnswerWhat does the evidence say about Fenugreek Cardiometabolic Randomized Trial?Legacy library material — check the original sources.AnswerWhat does the evidence say about Myo-Inositol Cardiometabolic Markers Randomized Trial?Legacy library material — check the original sources.AnswerWhat does the evidence say about Alpha-Lipoic Acid Cardiometabolic Markers Randomized Trial?Legacy library material — check the original sources.AnswerWhat does the evidence say about Green Tea Extract Cardiometabolic Markers Randomized Trial?Legacy library material — check the original sources.

Source documents

  1. Role of Functional Foods and Nutraceutical Compounds in Alleviating Polycystic Ovary Syndrome: A Narrative Review.
  2. Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study