Structured evidence table for Ergothioneine Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Ergothioneine Cognition Meta-Analysis | 3 4 [5] [6] [7] [8] 9 10 Previous studies have associated dementia risk with socioeconomic status (SES), a comprehensive concept that measured a person’s position from income, education and occupation [,]. | 3 | Zhao Xingguang (2026) | Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by Mendelian randomization |
| Ergothioneine Cognition Meta-Analysis | Evidence suggests that SES may influence cognitive function through multiple mediating pathways, including lifestyle behaviors, depressive symptoms, and vascular risk factors [,,,], highlighting potential targets for interventions to reduce the burden of dementia. | 3 | Zhao Xingguang (2026) | Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by Mendelian randomization |
| Ergothioneine Cognition Meta-Analysis | Diet quality generally improved with income [], while low-income families tend to purchase unhealthy food products rather than intake of enough types and frequency of healthy foods including vegetables and fruits, neglecting the nutritional quality of foods []. | 3 | Zhao Xingguang (2026) | Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by Mendelian randomization |
| Ergothioneine Cognition Meta-Analysis | 1 2 Dementia, including Alzheimer's disease (AD), is one of the primary causes of disability and death among the older people, and represents a serious public health issue []. | 3 | Zhao Xingguang (2026) | Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by Mendelian randomization |
| Ergothioneine Cognition Meta-Analysis | Cognitive frailty not only affects the quality of life of older adults but also significantly increases the risk of severe adverse outcomes such as dementia and disability []. | 3 | Gede Arjun M. M. I. (2025) | Advances and prospects of ergothioneine in the treatment of cognitive frailty |
| Ergothioneine Cognition Meta-Analysis | Research has demonstrated that ERGO exhibits significant protective effects against 7-ketocholesterol (7KC)-induced mitochondrial damage in human brain endothelial cells, as evidenced by improved cell viability, reduced intracellular calcium levels, decreased reactive oxygen species, and modulated expression of inflammatory markers []. | 3 | Gede Arjun M. M. I. (2025) | Advances and prospects of ergothioneine in the treatment of cognitive frailty |
| Ergothioneine Cognition Meta-Analysis | In numerous studies on the severity of coronavirus infection, hypoxia-induced respiratory distress, cytokine storm-induced central nervous system (CNS) inflammatory damage, and hypercoagulability leading to cerebral venous thrombosis or stroke have all been identified as major risk factors for mortality or severe symptoms []. | 3 | Gede Arjun M. M. I. (2025) | Advances and prospects of ergothioneine in the treatment of cognitive frailty |
| Ergothioneine Cognition Meta-Analysis | 1 2 3 4 Cognitive frailty, first formally proposed by the International Society of Nutrition and Aging and the International Geriatrics and Gerontology Association in 2013, is a clinical state where physical frailty and cognitive impairment coexist. | 3 | Gede Arjun M. M. I. (2025) | Advances and prospects of ergothioneine in the treatment of cognitive frailty |
Source documents