Structured evidence table for Eggshell Membrane Joint Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Eggshell Membrane Joint Health Randomized Trial | In PBMC assays, Biova ® increased IL-6 after lipopolysaccharide stimulation, showed a non-significant TNFα reduction, and had no effect on IL-17 A or granzyme B. | 4 | Gegel S (2026) | Clinical plausibility of eggshell membrane proteins for osteoarthritis: a study of solubility, digestibility, and immune response. |
| Eggshell Membrane Joint Health Randomized Trial | Supplements are commonly used by osteoarthritis (OA) patients, and eggshell membrane (ESM) proteins are widely advertised as natural bioactive compounds for joint health. | 4 | Gegel S (2026) | Clinical plausibility of eggshell membrane proteins for osteoarthritis: a study of solubility, digestibility, and immune response. |
| Eggshell Membrane Joint Health Randomized Trial | Here, we evaluated the solubility, digestibility, and immunomodulatory potential of commercial ESM supplements under physiologically relevant conditions to assess their plausibility as anti-inflammatory agents. | 4 | Gegel S (2026) | Clinical plausibility of eggshell membrane proteins for osteoarthritis: a study of solubility, digestibility, and immune response. |
| Eggshell Membrane Joint Health Randomized Trial | Results ESMP inhibited IL-1β-induced NF-κB p65 nuclear translocation and reduced the IL-1β-induced increases in interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-13 (MMP-13) at both mRNA and protein levels. | 4 | Mao X (2026) | Eggshell Membrane Peptides Alleviate IL-1β-Induced Inflammatory Responses and Extracellular Matrix Degradation in Canine Chondrocytes by Inhibiting the NF-κB Signaling Pathway. |
| Eggshell Membrane Joint Health Randomized Trial | Conclusions ESMP attenuates IL-1β-induced inflammatory responses and extracellular matrix degradation in canine chondrocytes, potentially associated with suppression of NF-κB p65 nuclear translocation. | 4 | Mao X (2026) | Eggshell Membrane Peptides Alleviate IL-1β-Induced Inflammatory Responses and Extracellular Matrix Degradation in Canine Chondrocytes by Inhibiting the NF-κB Signaling Pathway. |
| Eggshell Membrane Joint Health Randomized Trial | Background Eggshell membrane peptides (ESMPs) are natural bioactive compounds with reported chondroprotective properties. | 4 | Mao X (2026) | Eggshell Membrane Peptides Alleviate IL-1β-Induced Inflammatory Responses and Extracellular Matrix Degradation in Canine Chondrocytes by Inhibiting the NF-κB Signaling Pathway. |
| Eggshell Membrane Joint Health Randomized Trial | This study investigated ESMP in an interleukin-1β (IL-1β)-induced inflammatory model of canine chondrocytes. | 4 | Mao X (2026) | Eggshell Membrane Peptides Alleviate IL-1β-Induced Inflammatory Responses and Extracellular Matrix Degradation in Canine Chondrocytes by Inhibiting the NF-κB Signaling Pathway. |
Source documents