Structured evidence table for Curcumin Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Curcumin Stress Randomized Trial | 1 2 Arthritis constitutes a major global health burden and remains one of the leading causes of chronic pain, disability, and reduced quality of life worldwide. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Stress Randomized Trial | OA is primarily a degenerative disease associated with aging and mechanical stress, whereas RA is an autoimmune disorder characterized by systemic inflammation and synovial hyperplasia [,]. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Stress Randomized Trial | Although these therapies can alleviate symptoms and, in some cases, slow disease progression, their long-term use is often associated with significant adverse effects, including gastrointestinal, cardiovascular, renal, and immunological complications []. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Stress Randomized Trial | The two most prevalent forms, osteoarthritis (OA) and rheumatoid arthritis (RA), differ in etiology but share common pathological features, including joint inflammation, cartilage degradation, and progressive functional impairment. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Stress Randomized Trial | Obesity substantially increases the risk of serious obesity-related comorbidities, including diabetes mellitus, cardiovascular diseases, and multiple types of cancer (). | 3 | Liu Shan (2026) | A bibliometric analysis of research on the anti-obesity effects of curcumin from 2006 to 2025: knowledge structure, research hotspots, and evolution of frontiers |
| Curcumin Stress Randomized Trial | Pharmacological treatments, including glucagon-like peptide-1(GLP-1) receptor agonists such as semaglutide and lipase inhibitors such as orlistat, have demonstrated efficacy in weight management; however they may be associated with gastrointestinal adverse effects and other safety concerns (,). | 3 | Liu Shan (2026) | A bibliometric analysis of research on the anti-obesity effects of curcumin from 2006 to 2025: knowledge structure, research hotspots, and evolution of frontiers |
| Curcumin Stress Randomized Trial | Although metabolic surgery is highly effective in inducing weight loss, its widespread application is limited by high costs, strict eligibility criteria, and the risk of postoperative complications (). | 3 | Liu Shan (2026) | A bibliometric analysis of research on the anti-obesity effects of curcumin from 2006 to 2025: knowledge structure, research hotspots, and evolution of frontiers |
| Curcumin Stress Randomized Trial | 1 2 3 4 5 Obesity has become one of the most pressing global public health challenges. | 3 | Liu Shan (2026) | A bibliometric analysis of research on the anti-obesity effects of curcumin from 2006 to 2025: knowledge structure, research hotspots, and evolution of frontiers |
Source documents