evidence table

Curcumin and Osteoarthritis Evidence Table

Structured evidence table for Curcumin and Osteoarthritis, generated from 3 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Curcumin and OsteoarthritisNational dietary guidelines from several countries (eg, the United States, United Kingdom, and Australia) recommend the consumption of spices to lower sodium intake.The National Institutes of Health (NIH)–funded Dietary Approaches to Stop Hypertension (DASH) healthy eating plan replaces salt with spices and herbs as a means to lower blood pressure without medication.3Diacova Tatiana (2026)Spices Beyond Antioxidants: From the Gut to the Brain
Curcumin and OsteoarthritisIt was also demonstrated that salt intake was associated with regional metabolic activity in the insula and orbitofrontal cortex (OFC) areas of the brain.The administration of capsaicin (chili pepper) in the Li et al.3Diacova Tatiana (2026)Spices Beyond Antioxidants: From the Gut to the Brain
Curcumin and Osteoarthritis(2013) To investigate whether spice (poly)phenols reduce GI and systemic formation of cytotoxic lipid peroxidation products and increase NO formation, thereby leading to improved endothelial vascular function n  = 11 men with type 2 diabetes RCT 2 test meals, 1 wk apart  Zhang et al.3Diacova Tatiana (2026)Spices Beyond Antioxidants: From the Gut to the Brain
Curcumin and OsteoarthritisHerbs and spices have been used in various countries around the world for centuries.3Diacova Tatiana (2026)Spices Beyond Antioxidants: From the Gut to the Brain
Curcumin and Osteoarthritis1 2 Arthritis constitutes a major global health burden and remains one of the leading causes of chronic pain, disability, and reduced quality of life worldwide.3Toumi Hechmi (2026)Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
Curcumin and OsteoarthritisOA is primarily a degenerative disease associated with aging and mechanical stress, whereas RA is an autoimmune disorder characterized by systemic inflammation and synovial hyperplasia [,].3Toumi Hechmi (2026)Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
Curcumin and OsteoarthritisAlthough these therapies can alleviate symptoms and, in some cases, slow disease progression, their long-term use is often associated with significant adverse effects, including gastrointestinal, cardiovascular, renal, and immunological complications [].3Toumi Hechmi (2026)Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
Curcumin and OsteoarthritisThe two most prevalent forms, osteoarthritis (OA) and rheumatoid arthritis (RA), differ in etiology but share common pathological features, including joint inflammation, cartilage degradation, and progressive functional impairment.3Toumi Hechmi (2026)Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
Curcumin and OsteoarthritisEmerging evidence suggests that combining structured exercise with nano-curcumin, a bioavailable phytochemical formulation with potent antioxidant and anti-inflammatory properties, may provide synergistic benefits.3Cherappurath N (2025)Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
Curcumin and OsteoarthritisThis scoping review systematically synthesizes available evidence on the combined effects of nano-curcumin supplementation and exercise interventions on health outcomes in women with lifestyle-related diseases.3Cherappurath N (2025)Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
Curcumin and OsteoarthritisWhen paired with nano-curcumin supplementation at different concentrations, high-intensity interval training, aerobic exercise, Pilates, and resistance training consistently outperformed exercise or supplementation alone in modulating antioxidant defenses, reducing systemic inflammation, and improving metabolic risk factors.3Cherappurath N (2025)Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
Curcumin and OsteoarthritisBackground/Objectives: Lifestyle-related diseases such as obesity, diabetes, hypertension, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis disproportionately affect women due to hormonal, metabolic, and socio-cultural factors.3Cherappurath N (2025)Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
topicCurcumin and Osteoarthritis
claimNational dietary guidelines from several countries (eg, the United States, United Kingdom, and Australia) recommend the consumption of spices to lower sodium intake.The National Institutes of Health (NIH)–funded Dietary Approaches to Stop Hypertension (DASH) healthy eating plan replaces salt with spices and herbs as a means to lower blood pressure without medication.
evidence level3
citationDiacova Tatiana (2026)
sourceSpices Beyond Antioxidants: From the Gut to the Brain
topicCurcumin and Osteoarthritis
claimIt was also demonstrated that salt intake was associated with regional metabolic activity in the insula and orbitofrontal cortex (OFC) areas of the brain.The administration of capsaicin (chili pepper) in the Li et al.
evidence level3
citationDiacova Tatiana (2026)
sourceSpices Beyond Antioxidants: From the Gut to the Brain
topicCurcumin and Osteoarthritis
claim(2013) To investigate whether spice (poly)phenols reduce GI and systemic formation of cytotoxic lipid peroxidation products and increase NO formation, thereby leading to improved endothelial vascular function n  = 11 men with type 2 diabetes RCT 2 test meals, 1 wk apart  Zhang et al.
evidence level3
citationDiacova Tatiana (2026)
sourceSpices Beyond Antioxidants: From the Gut to the Brain
topicCurcumin and Osteoarthritis
claimHerbs and spices have been used in various countries around the world for centuries.
evidence level3
citationDiacova Tatiana (2026)
sourceSpices Beyond Antioxidants: From the Gut to the Brain
topicCurcumin and Osteoarthritis
claim1 2 Arthritis constitutes a major global health burden and remains one of the leading causes of chronic pain, disability, and reduced quality of life worldwide.
evidence level3
citationToumi Hechmi (2026)
sourceCurcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
topicCurcumin and Osteoarthritis
claimOA is primarily a degenerative disease associated with aging and mechanical stress, whereas RA is an autoimmune disorder characterized by systemic inflammation and synovial hyperplasia [,].
evidence level3
citationToumi Hechmi (2026)
sourceCurcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
topicCurcumin and Osteoarthritis
claimAlthough these therapies can alleviate symptoms and, in some cases, slow disease progression, their long-term use is often associated with significant adverse effects, including gastrointestinal, cardiovascular, renal, and immunological complications [].
evidence level3
citationToumi Hechmi (2026)
sourceCurcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
topicCurcumin and Osteoarthritis
claimThe two most prevalent forms, osteoarthritis (OA) and rheumatoid arthritis (RA), differ in etiology but share common pathological features, including joint inflammation, cartilage degradation, and progressive functional impairment.
evidence level3
citationToumi Hechmi (2026)
sourceCurcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
topicCurcumin and Osteoarthritis
claimEmerging evidence suggests that combining structured exercise with nano-curcumin, a bioavailable phytochemical formulation with potent antioxidant and anti-inflammatory properties, may provide synergistic benefits.
evidence level3
citationCherappurath N (2025)
sourceSynergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
topicCurcumin and Osteoarthritis
claimThis scoping review systematically synthesizes available evidence on the combined effects of nano-curcumin supplementation and exercise interventions on health outcomes in women with lifestyle-related diseases.
evidence level3
citationCherappurath N (2025)
sourceSynergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
topicCurcumin and Osteoarthritis
claimWhen paired with nano-curcumin supplementation at different concentrations, high-intensity interval training, aerobic exercise, Pilates, and resistance training consistently outperformed exercise or supplementation alone in modulating antioxidant defenses, reducing systemic inflammation, and improving metabolic risk factors.
evidence level3
citationCherappurath N (2025)
sourceSynergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
topicCurcumin and Osteoarthritis
claimBackground/Objectives: Lifestyle-related diseases such as obesity, diabetes, hypertension, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis disproportionately affect women due to hormonal, metabolic, and socio-cultural factors.
evidence level3
citationCherappurath N (2025)
sourceSynergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.

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Source documents

  1. Spices Beyond Antioxidants: From the Gut to the Brain
  2. Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications
  3. Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.