Structured evidence table for Crocin Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Crocin Cognition Randomized Trial | In aged mice, the low dose prevented age-related weight loss and modulated hepatic lipid metabolism, whereas the high dose reduced anxiety-like behavior and improved recognition memory. | 4 | Navarro JA (2026) | Safranal-Standardized Saffron Extract Improves Metabolic, Cognitive, and Anxiolytic Outcomes in Aged Mice via Hypothalamic-Amygdalar Peptide Modulation. |
| Crocin Cognition Randomized Trial | The anxiolytic effects are consistent with elevated hypothalamic Npy , an anxiolytic peptide, reduced amygdalar Crh , a key mediator of stress and anxiety, and decreased hypothalamic Hcrt, an arousal modulator. | 4 | Navarro JA (2026) | Safranal-Standardized Saffron Extract Improves Metabolic, Cognitive, and Anxiolytic Outcomes in Aged Mice via Hypothalamic-Amygdalar Peptide Modulation. |
| Crocin Cognition Randomized Trial | The improvement in memory is associated with modulation of the cortical and hippocampal inflammatory and endocannabinoid proteins involved in neural plasticity. | 4 | Navarro JA (2026) | Safranal-Standardized Saffron Extract Improves Metabolic, Cognitive, and Anxiolytic Outcomes in Aged Mice via Hypothalamic-Amygdalar Peptide Modulation. |
| Crocin Cognition Randomized Trial | Background : Population aging increases susceptibility to cognitive decline, anxiety, and metabolic dysregulation, yet safe and effective interventions remain limited. | 4 | Navarro JA (2026) | Safranal-Standardized Saffron Extract Improves Metabolic, Cognitive, and Anxiolytic Outcomes in Aged Mice via Hypothalamic-Amygdalar Peptide Modulation. |
| Crocin Cognition Randomized Trial | There is currently no approved treatment for slowing cognitive decline in MS, aside from the benefits associated with disease-modifying treatments. | 4 | Rezaei Ali (2025) | Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review |
| Crocin Cognition Randomized Trial | Our review primarily focuses on the antioxidants with clinical evidence of cognitive effects (whether null, positive, or negative) in MS. | 4 | Rezaei Ali (2025) | Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review |
| Crocin Cognition Randomized Trial | Additionally, melatonin has been shown to modulate immune responses and inhibit pro-inflammatory cytokines, potentially attenuating the inflammatory cascade associated with MS progression. | 4 | Rezaei Ali (2025) | Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review |
| Crocin Cognition Randomized Trial | 1 [] 2 [] Multiple Sclerosis (MS) is a chronic autoimmune disorder characterized by demyelination and neurodegeneration in the central nervous system (CNS), resulting in a diverse range of symptoms arising from neurological dysfunction in these patients. | 4 | Rezaei Ali (2025) | Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review |
Source documents