topicCranberry Supplementation Oral Health Meta-Analysis
claimRandom-effects meta-analyses were conducted using the restricted maximum likelihood estimator, and the certainty of evidence was assessed using the GRADE framework.
evidence level1
citationGuevara Guevara EV (2026)
sourceEffects of Oral Berry Supplementation on Blood Pressure in Adults with Hypertension or Elevated Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCranberry Supplementation Oral Health Meta-Analysis
claimConclusions: Current evidence does not support a consistent effect of berry supplementation on blood pressure or related cardiometabolic outcomes in this population, given the low to very low certainty of the available evidence.
evidence level1
citationGuevara Guevara EV (2026)
sourceEffects of Oral Berry Supplementation on Blood Pressure in Adults with Hypertension or Elevated Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCranberry Supplementation Oral Health Meta-Analysis
claimBackground/Objective: Hypertension is a leading preventable cause of cardiovascular disease, affecting over one billion people worldwide.
evidence level1
citationGuevara Guevara EV (2026)
sourceEffects of Oral Berry Supplementation on Blood Pressure in Adults with Hypertension or Elevated Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCranberry Supplementation Oral Health Meta-Analysis
claimBerry-derived bioactive compounds may influence vascular function and blood pressure.
evidence level1
citationGuevara Guevara EV (2026)
sourceEffects of Oral Berry Supplementation on Blood Pressure in Adults with Hypertension or Elevated Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicCranberry Supplementation Oral Health Meta-Analysis
claimThey not only have a significant impact on quality of life and social well-being [,,] but, if left untreated or undertreated, they can increase the risk of developing various complications, including organ dysfunction [,] and genitourinary cancers [,,].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicCranberry Supplementation Oral Health Meta-Analysis
claimAmong these, polyphenols, which can be found in plants [] but also in microbial sources such as algae [], have been extensively studied in both preclinical and clinical settings [,,,,,,,,,,,].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicCranberry Supplementation Oral Health Meta-Analysis
claimThese effects may be at least partly attributed to the ability of natural ITCs to slowly release hydrogen sulfide (HS), a gasotransmitter with health-promoting properties [,,], whose biosynthesis is reduced during aging or under disease conditions [].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicCranberry Supplementation Oral Health Meta-Analysis
claim1 2 3 4 4 Genitourinary pathological conditions represent a growing global health threat, posing significant challenges not only for affected individuals, but also for caregivers and healthcare professionals [,,].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies