topicCordyceps Endurance Performance Randomized Trial
claimEdible fungi are rich in a wide array of bioactive compounds, and a growing body of evidence suggests that they possess anti-inflammatory, antioxidant, antitumor, anti-aging, and other beneficial properties.
evidence level1
citationShu MY (2025)
sourceEffects of fungal supplementation on endurance, immune function, and hematological profiles in adult athletes: a systematic review and meta-analysis.
topicCordyceps Endurance Performance Randomized Trial
claimAlthough an increasing number of studies have investigated the potential benefits of fungal supplements for athletes, there is still a lack of comprehensive reviews that systematically synthesize the available evidence.
evidence level1
citationShu MY (2025)
sourceEffects of fungal supplementation on endurance, immune function, and hematological profiles in adult athletes: a systematic review and meta-analysis.
topicCordyceps Endurance Performance Randomized Trial
claimMeta-analysis showed that Cordyceps sinensis supplementation significantly improved endurance performance ( p = 0.05), ventilatory threshold ( p = 0.03), and VO 2 peak ( p = 0.04), indicating enhanced aerobic capacity with low heterogeneity.
evidence level1
citationShu MY (2025)
sourceEffects of fungal supplementation on endurance, immune function, and hematological profiles in adult athletes: a systematic review and meta-analysis.
topicCordyceps Endurance Performance Randomized Trial
claimEmerging empirical evidence indicates that a simultaneous approach targeting mitochondrial function, one-carbon metabolism, and catecholaminergic pathways may yield a more efficacious strategy than isolated interventions ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Endurance Performance Randomized Trial
claimThe dysregulation of methylation pathways has been associated with the onset of metabolic syndrome, cognitive decline, and muscular dysfunction ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Endurance Performance Randomized Trial
claimThe process of aging, along with metabolic disorders, is often correlated with compromised dopaminergic signaling, which contributes to diminished physical performance and increased levels of fatigue.
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Endurance Performance Randomized Trial
claim1 2 3 4 5 6 7 8 9 Athletic performance represents a multifaceted phenotype influenced by the interplay of mitochondrial bioenergetics, epigenetic modulation, and neurotransmitter signaling ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations