evidence table

Collagen Muscle Recovery Randomized Trial Evidence Table

Structured evidence table for Collagen Muscle Recovery Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Collagen Muscle Recovery Randomized Trial1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Collagen Muscle Recovery Randomized Trial1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Collagen Muscle Recovery Randomized TrialLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Collagen Muscle Recovery Randomized TrialIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Collagen Muscle Recovery Randomized TrialEVs represent an acellular biologic platform that recapitulates key paracrine effects of stem cells while avoiding risks associated with live-cell transplantation.4Chung Seok Won (2026)Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
Collagen Muscle Recovery Randomized Trialidentified a lineage-restricted, non-fibro-adipogenic pericyte population derived from human embryonic stem cells that attenuated muscle degeneration in a chronic RC injury model.These PDGFR-βPDGFR-αpericytes resisted fibrotic and adipogenic remodeling, reduced collagen deposition, and limited myofiber atrophy, supporting a niche-stabilizing, paracrine mechanism rather than direct myogenic replacement.4Chung Seok Won (2026)Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
Collagen Muscle Recovery Randomized Trialconducted a systematic review of 46 preclinical studies examining exosome-based therapies for tendon and tendon-to-bone interface healing.Although these models provide indirect insight into the muscle environment, direct evidence of RC muscle regeneration was limited.4Chung Seok Won (2026)Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
Collagen Muscle Recovery Randomized Trial, , , , Biologic therapies exert regenerative and anti-fibrotic effects primarily by modulating cellular behavior and intercellular signaling within the injured RC muscle microenvironment.4Chung Seok Won (2026)Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
topicCollagen Muscle Recovery Randomized Trial
claim1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicCollagen Muscle Recovery Randomized Trial
claim1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicCollagen Muscle Recovery Randomized Trial
claimLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicCollagen Muscle Recovery Randomized Trial
claimIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicCollagen Muscle Recovery Randomized Trial
claimEVs represent an acellular biologic platform that recapitulates key paracrine effects of stem cells while avoiding risks associated with live-cell transplantation.
evidence level4
citationChung Seok Won (2026)
sourceInhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
topicCollagen Muscle Recovery Randomized Trial
claimidentified a lineage-restricted, non-fibro-adipogenic pericyte population derived from human embryonic stem cells that attenuated muscle degeneration in a chronic RC injury model.These PDGFR-βPDGFR-αpericytes resisted fibrotic and adipogenic remodeling, reduced collagen deposition, and limited myofiber atrophy, supporting a niche-stabilizing, paracrine mechanism rather than direct myogenic replacement.
evidence level4
citationChung Seok Won (2026)
sourceInhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
topicCollagen Muscle Recovery Randomized Trial
claimconducted a systematic review of 46 preclinical studies examining exosome-based therapies for tendon and tendon-to-bone interface healing.Although these models provide indirect insight into the muscle environment, direct evidence of RC muscle regeneration was limited.
evidence level4
citationChung Seok Won (2026)
sourceInhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism
topicCollagen Muscle Recovery Randomized Trial
claim, , , , Biologic therapies exert regenerative and anti-fibrotic effects primarily by modulating cellular behavior and intercellular signaling within the injured RC muscle microenvironment.
evidence level4
citationChung Seok Won (2026)
sourceInhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism

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Source documents

  1. Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
  2. Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism