Structured evidence table for Collagen Joint Stiffness Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Collagen Joint Stiffness Randomized Trial | Osteoarthritis (OA) is prevalent in the Indian subcontinent and Southeast Asia, causing pain, reduced mobility, and disability. | 4 | Prabhoo R (2026) | Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion. |
| Collagen Joint Stiffness Randomized Trial | An evidence-based analysis showed that undenatured type II collagen (40 mg/day) improves pain, stiffness, function, and quality of life in early-to-moderate OA (Grades 1-3), with benefits observed within eight weeks, improved compliance, and non-steroidal anti-inflammatory drug-sparing effects. | 4 | Prabhoo R (2026) | Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion. |
| Collagen Joint Stiffness Randomized Trial | Comparative evidence favors UC-II® (Lonza Greenwood LLC, USA) over other sources, highlighting the importance of product selection. | 4 | Prabhoo R (2026) | Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion. |
| Collagen Joint Stiffness Randomized Trial | Genetic, lifestyle, and comorbidity factors contribute to earlier onset and more severe disease than in Western populations. | 4 | Prabhoo R (2026) | Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion. |
| Collagen Joint Stiffness Randomized Trial | Background The molecular and histologic characteristics associated with the development of post-traumatic capsular fibrosis of the shoulder joint following open reduction and internal fixation (ORIF) of proximal humerus fractures (PHF) remain incompletely understood. | 4 | Henssler L (2026) | Gene expression and histological assessment of capsular fibrosis in post-traumatic shoulder stiffness following plate fixation of proximal humeral fractures: an exploratory pilot study. |
| Collagen Joint Stiffness Randomized Trial | Histological assessments demonstrated features of capsular fibrosis, including increased extracellular matrix deposition and disorganized collagen architecture. | 4 | Henssler L (2026) | Gene expression and histological assessment of capsular fibrosis in post-traumatic shoulder stiffness following plate fixation of proximal humeral fractures: an exploratory pilot study. |
| Collagen Joint Stiffness Randomized Trial | Histology found mature fibrosis while molecular analysis could identify candidate genes as potential target for further research. | 4 | Henssler L (2026) | Gene expression and histological assessment of capsular fibrosis in post-traumatic shoulder stiffness following plate fixation of proximal humeral fractures: an exploratory pilot study. |
| Collagen Joint Stiffness Randomized Trial | To help elucidate these mechanisms, this hypothesis-generating pilot study aimed to examine gene expression and histological changes in the joint capsule of patients undergoing implant removal and adhesiolysis for post-traumatic stiffness after surgical fixation of PHF. | 4 | Henssler L (2026) | Gene expression and histological assessment of capsular fibrosis in post-traumatic shoulder stiffness following plate fixation of proximal humeral fractures: an exploratory pilot study. |
Source documents